CONTROLLED TRIAL OF GLYCEROL VERSUS DEXAMETHASONE IN THE TREATMENT OF CEREBRAL (EDEMA IN ACUTE CEREBRAL INFARCTION
CONTROLLED TRIAL OF GLYCEROL VERSUS DEXAMETHASONE IN THE TREATMENT OF CEREBRAL (EDEMA IN ACUTE CEREBRAL INFARCTION
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甘油与地塞米松治疗脑病（急性脑梗塞水肿）的对照试验
DOI：
10.1016/s0140-6736(75)91825-5
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
Chantres Mt
中科院分区：
文献类型：
--
作者：
V. Gilsanz;J. Buencuerpo;J. Rebollar;Chantres Mt
对30例急性缺血性脑梗死患者给予10%甘油治疗6天，并与31例类似患者给予地塞米松治疗（16 mg / 24 h，连续6天）的结果进行比较。甘油治疗1例死于h型血红蛋白尿和急性肾功能衰竭。6例使用地塞米松治疗的患者死亡，其中3例死于脑œdema， 3例死于非神经系统并发症（肺栓塞、心肌梗死和吸入性肺炎）。在8天和15天后，甘油组的改善明显更大。7例自发性脑内出血患者使用甘油或地塞米松均未见改善。
10% glycerol was given for 6 days to 30 patients who had had an acute ischæmic cerebral infarction, and the results were compared with those obtained after treating 31 similar patients with dexamethasone (16 mg. per 24 hours for 6 days). 1 patient treated with glycerol died of hæmoglobinuria and acute renal failure. 6 patients treated with dexamethasone died—3 from cerebral œdema and 3 from non-neurological complications (pulmonary embolism, myocardial infarction, and aspiration pneumonia). Improvement was significantly greater in the glycerol group after 8 and 15 days. No improvement was noted using either glycerol or dexamethasone in 7 patients with spontaneous intra-cerebral hæmorrhage.