Transcription of genes encoding trans-acting factors required for rRNA maturation/ribosomal subunit assembly is coordinately regulated with ribosomal protein genes and involves Rap1 in Saccharomyces cerevisiae
Transcription of genes encoding trans-acting factors required for rRNA maturation/ribosomal subunit assembly is coordinately regulated with ribosomal protein genes and involves Rap1 in Saccharomyces cerevisiae
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DOI：
10.1093/nar/gkg278
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发表时间：
2003-04-01
影响因子：
14.9
通讯作者：
Mizuta, K
中科院分区：
文献类型：
--
作者：
Miyoshi, K;Shirai, C;Mizuta, K
我们表明，前rRNA加工/核糖体亚基组装所必需的反式作用因子编码基因是响应于各种压力，如热休克，氮剥夺和分泌缺陷，在协调与核糖体蛋白基因在酿酒酵母。产生转录因子Rap 1 p的C-末端截短蛋白的rap 1 -17突变，由于先前对于核糖体蛋白和rRNA基因所示的分泌缺陷而影响反式作用因子基因的转录抑制。
We demonstrate that the genes encoding transacting factors essential for pre-rRNA processing/ribosomal subunit assembly are responsive to various kinds of stresses such as heat shock, nitrogen deprivation and a secretory defect, in coordination with ribosomal protein genes in Saccharomyces cerevisiae. The rap1-17 mutation, which produces the C-terminally truncated protein of a transcriptional factor Rap1p, affects transcriptional repression of the trans-acting factor genes due to a secretory defect as shown previously for both ribosomal protein and rRNA genes.