HIV Pathogenesis in the Human Female Reproductive Tract.
HIV Pathogenesis in the Human Female Reproductive Tract.
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DOI：
10.1007/s11904-021-00546-1
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发表时间：
2021-04
影响因子：
4.6
通讯作者：
Ghosh, Mimi
中科院分区：
文献类型：
--
作者：
Rodriguez-Garcia, Marta;Connors, Kaleigh;Ghosh, Mimi
Women remain disproportionately affected by the HIV/AIDS pandemic. The primary mechanism for HIV acquisition in women is sexual transmission, yet the immunobiological factors that contribute to HIV susceptibility remain poorly characterized. Here we review current knowledge on HIV pathogenesis in women, focusing on infection and immune responses in the female reproductive tract (FRT). We describe recent findings on innate immune protection and HIV target cell distribution in the FRT. We also review multiple factors that modify susceptibility to infection, including sex hormones, microbiome, trauma and how HIV risk changes during women’s life cycle. Finally, we review current strategies for HIV prevention and identify barriers for research in HIV infection and pathogenesis in women. A complex network of interrelated biological and sociocultural factors contributes to HIV risk in women and impairs prevention and cure strategies. Understanding how HIV establishes infection in the FRT can provide clues to develop novel interventions to prevent HIV acquisition in women.
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影响因子：
3.7
作者：
Lahey T;Ghosh M;Fahey JV;Shen Z;Mukura LR;Song Y;Cu-Uvin S;Mayer KH;Wright PF;Kappes JC;Ochsenbauer C;Wira CR
通讯作者：
Wira CR
影响因子：
168.9
作者：
Baeten, Jared M.;Donnell, Deborah;Stringer, Jeffrey
通讯作者：
Stringer, Jeffrey
影响因子：
1.5
作者：
Calenda, Giulia;Villegas, Guillermo;Teleshova, Natalia
通讯作者：
Teleshova, Natalia
影响因子：
9.8
作者：
Anderson, Brenna L.;Ghosh, Mimi;Cu-Uvin, Susan
通讯作者：
Cu-Uvin, Susan
影响因子：
6.4
作者：
Bere, Alfred;Denny, Lynette;Passmore, Jo-Ann S.
通讯作者：
Passmore, Jo-Ann S.