Oxidative stress in preeclamptic mother - newborn dyads and its correlation with early neonatal outcome - a case control study
Oxidative stress in preeclamptic mother - newborn dyads and its correlation with early neonatal outcome - a case control study
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DOI：
10.1080/14767058.2017.1319933
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发表时间：
2018-01-01
影响因子：
1.8
通讯作者：
Habeebullah, S.
中科院分区：
文献类型：
--
作者：
Bharadwaj, Shruti;Bhat, Vishnu B.;Habeebullah, S.
工作背景：先兆子痫的母亲在怀孕期间很可能有增加的氧化应激，这可能会对他们的新生儿的结局产生不利影响。目的：测量先兆子痫的母亲-新生儿二联体中的氧化应激，并将其与新生儿的直接结局相关联。这项病例对照研究在一家三级护理教学医院进行，南印度包括71名先兆子痫母亲-新生儿二联体（病例）和72名正常母亲-新生儿二联体（对照）。检测母血和脐带血中总抗氧化状态（TAS）、蛋白质羰基化和丙二醛（MDA）水平。这些氧化应激参数和早期新生儿outcome.Results之间的关联进行了研究：所有氧化应激标志物均高于子痫前期组相比，对照组。脐血蛋白羰基水平与母体水平显著相关。早产、低出生体重、呼吸窘迫综合征、早发型败血症和宫内生长受限的发生率较高。早期新生儿结局如死亡、IUGR、EOS和RDS与蛋白质羰基水平显著相关。结论：氧化应激在先兆子痫的母亲-新生儿中增加。先兆子痫患者蛋白质羰基水平升高与早期新生儿不良结局相关。
Background: Preeclamptic mothers are likely to have increased oxidative stress during pregnancy which can adversely affect the outcome in their neonates.Objectives: To measure the oxidative stress in preeclamptic mother- newborn dyads and correlate it with the immediate neonatal outcome.Methods: This case control study conducted in a tertiary care teaching hospital, South India included 71 preeclamptic mothers - newborn dyads (cases) and 72 normal mothers - newborn dyads (controls). Biochemical parameters including total antioxidant status (TAS), protein carbonyls and malondialdehyde levels (MDA) were measured in both maternal and cord blood. Association between these oxidative stress parameters and early neonatal outcome was studied.Results: All oxidative stress markers were higher in the preeclampsia group compared to the controls. Cord blood protein carbonyl levels had significant correlation with maternal levels. Prematurity, low-birth weight, respiratory distress syndrome (RDS), early onset sepsis (EOS) and intra-uterine growth restriction (IUGR) were more among cases. Early neonatal outcomes like death, IUGR, EOS, and RDS had significant correlation with protein carbonyl levels among the cases.Conclusions: Oxidative stress is increased in preeclamptic mother - newborn dyads. Increased protein carbonyl levels in preeclampsia correlate with adverse early neonatal outcome.