Immunoglobulin superfamily cell adhesion molecules: zippers and signals
Immunoglobulin superfamily cell adhesion molecules: zippers and signals
复制标题
DOI：
10.1016/j.ceb.2007.09.010
复制
发表时间：
2007-10-01
影响因子：
7.5
通讯作者：
Jones, E. Yvonne
中科院分区：
文献类型：
--
作者：
Aricescu, A. Radu;Jones, E. Yvonne
免疫球蛋白超家族细胞粘附分子的最新结构研究正在推动观点的转变;越来越多的观点不仅仅集中在单个分子上，而是集中在分子组装上。两个共同的主题正在出现，揭示了细胞表面受体信号传导能力的胞外区依赖性调节机制。首先是许多这样的分子倾向于排列在拉链型或阵列型组件驱动的高度特定的顺式和反式相互作用的网络。第二种是使用分子或粘附复合物的细胞外尺寸作为特性，其与特征性细胞间间距结合，可以确定特定蛋白质群体在细胞界面和连接处的共定位或排斥。
The latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a shift in perspective; increasingly the view is not focused solely on the individual molecule but rather is on the molecular assembly. Two common themes are emerging, revealing mechanisms for ectodomain-dependent regulation of cell surface receptors' signalling abilities. The first is the propensity of many such molecules to arrange in zipper-type or array-type assemblies driven by a network of highly specific cis and trans interactions. The second is the use of the extracellular dimensions of a molecule or adhesion complex as properties which, in combination with characteristic intercellular spacings, can determine the co-localisation or exclusion of particular protein populations at cell interfaces and junctions.