CHANGES IN THE SECRETORY ACINAR-CELLS OF THE RAT PAROTID-GLAND DURING AGING
CHANGES IN THE SECRETORY ACINAR-CELLS OF THE RAT PAROTID-GLAND DURING AGING
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DOI：
10.1002/ar.1092090313
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
KIM, SK
中科院分区：
文献类型：
--
作者：
KIM, SK
通过电镜检查不同年龄大鼠腮腺的分泌腺泡细胞，以确定这些细胞中发生的与年龄相关的变化。这些细胞中最显着的变化是脂褐质颗粒的数量随着年龄的增长而逐渐增加。脂褐质颗粒是由脂质、其他子成分和基质组成的膜结合结构。此外，这些细胞含有不与任何其他成分相关的脂滴，并且往往积聚在老年大鼠的细胞底部。此外，老年大鼠腺体中的许多腺泡细胞含有改变的分泌颗粒，这些颗粒似乎正处于退化过程中。脂质的积累和退化的分泌颗粒似乎与老年大鼠腺体中细胞分泌活性水平的降低有关。这两种类型的内含物可能有助于脂褐质颗粒的形成。脂褐素和退化分泌颗粒与酸性磷酸酶相关，这在细胞化学上得到证实，表明这些颗粒是溶酶体结构。
The secretory acinar cells of parotid glands from rats of varying ages were examined by EM to determine what age-related changes occur in these cells. The most prominent change noted in these cells is the progressive increase in the amount of lipofuscin granules with age. Lipofuscin granules are membrane-bound structures consisting of lipids, other subcomponents and a matrix. In addition, these cells contain lipid droplets that are not associated with any other components and tend to accumulate at the base of the cells in older rats. Also, many acinar cells in the glands of old rats contain altered secretory granules which appear to be in the process of degeneration. The accumulation of lipid and degenerating secretory granules appears to be related to the reduced level of cellular secretory activity in the glands of older rats. It is possible that these 2 types of inclusions contribute to the formation of lipofuscin granules. Lipofuscin and degenerating secretory granules are associated with acid phosphatase, which is demonstrated cytochemically, indicating that these granules are lysosomal structures.