Experimental leprosy in three species of monkeys.
Experimental leprosy in three species of monkeys.
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三种猴子的实验性麻风病。
DOI：
10.1126/science.3917577
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Binford,CH
中科院分区：
文献类型：
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作者：
Wolf,RH;Gormus,BJ;Martin,LN;Baskin,GB;Walsh,GP;Meyers,WM;Binford,CH
十一只白眉猴接种了麻风分枝杆菌，患上了麻风病。其中九只白眉猴接种了 M.麻风病是从患有自然获得性麻风病的白眉猴身上分离出来的。疾病传播后，其中一些动物的免疫功能受到抑制。两只白眉猴在接种人类M后患上了麻风病。麻风病在犰狳体内传代。三只恒河猴和三只非洲绿猴接种了源自白眉猴的M。麻风病也发展为麻风病。白眉猴可能是第一个报道的用于麻风病研究的非人类灵长类动物模型。恒河猴和非洲绿猴也可能被证明对这种疾病具有可重复的易感性。
Eleven mangabey monkeys inoculated withMycobacterium lepraedeveloped lepromatous-type leprosy. Nine of the mangabeys were inoculated withM. lepraeisolated from a mangabey with naturally acquired lepromatous leprosy. Immune function was depressed in some of these animals after dissemination of the disease. Two mangabeys developed lepromatous leprosy after inoculation with humanM. lepraepassaged in an armadillo. Three rhesus and three African green monkeys inoculated with mangabey-derivedM. lepraealso developed lepromatous leprosy. Mangabeys may be the first reported nonhuman primate model for the study of leprosy. Rhesus and African green monkeys may also prove to be reproducibly susceptible to the disease.