MICROSURGICAL TRANSFER OF THE GREATER OMENTUM IN THE TREATMENT OF CANINE OBSTRUCTIVE LYMPHEDEMA
MICROSURGICAL TRANSFER OF THE GREATER OMENTUM IN THE TREATMENT OF CANINE OBSTRUCTIVE LYMPHEDEMA
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DOI：
10.1016/0007-1226(90)90010-w
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发表时间：
1990-07-01
期刊：
影响因子：
--
通讯作者：
PRIBAZ, JJ
中科院分区：
文献类型：
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作者：
OBRIEN, BM;HICKEY, MJ;PRIBAZ, JJ
在13只狗中，采用放射治疗和根治性腹股沟清扫术联合建立了实验性下肢梗阻性淋巴水肿。六个月后，当淋巴水肿的程度稳定时，通过游离大网膜移植物的微血管插入来桥接淋巴阻塞。移植后6个月，周向测量表明淋巴水肿程度统计学显著降低38%。活组织检查显示网膜移植物是活的，但含有大量纤维组织。11例活检中有10例发现淋巴管，但这些淋巴管与移植物近端淋巴管之间的连接无法通过淋巴管造影或染料注射技术证明。研究结果表明，实验性阻塞性淋巴水肿的狗可以减少显着插入血管网膜移植。然而，不能确定改善是由于移植物淋巴管与淋巴水肿肢体的淋巴管的愈合，尽管这种愈合可能包括太小而无法证明的淋巴管。
In 13 dogs, experimental obstructive lymphoedema of the lower limb was created by combined radiotherapy and radical groin dissection. Six months later, when the degree of lymphoedema was stable, the lymphatic obstruction was bridged by microvascular insertion of a free omental graft. Six months after grafting, circumferential measurements indicated a statistically significant 38% reduction in the magnitude of lymphoedema. Biopsies showed the omental grafts were alive but contained much fibrous tissue. Lymphatic vessels were identified in 10 of 11 biopsies but connections between these lymphatics and lymphatics proximal to the graft could not be demonstrated by either lymphangiography or dye-injection techniques. The findings indicate that experimental obstructive lymphoedema in the dog can be reduced significantly by insertion of a vascularised omental graft. However, it could not be established that improvement was due to union of graft lymphatics with those of the lymphoedematous limb, although this union may have consisted of lymphatics too small to be demonstrated.