Serum Magnesium Concentrations in the Canadian Population and Associations with Diabetes, Glycemic Regulation, and Insulin Resistance
Serum Magnesium Concentrations in the Canadian Population and Associations with Diabetes, Glycemic Regulation, and Insulin Resistance
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DOI：
10.3390/nu9030296
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发表时间：
2017-03-01
期刊：
影响因子：
5.9
通讯作者：
Hayward, Stephen
中科院分区：
文献类型：
--
作者：
Bertinato, Jesse;Wang, Kuan Chiao;Hayward, Stephen
血清总镁（Mg）浓度（SMC）通常用于评估镁的状态。本研究使用加拿大健康措施调查周期3（2012-2013）的结果，报告了目前加拿大人的SMCs及其与人口因素、糖尿病、血糖控制措施和胰岛素抵抗的关系。使用线性混合模型对20-79岁的成年人进行相关性研究。报告了3 - 79岁11个性别年龄组（n = 5561）的平均SMCs和百分位数分布。SMCs呈正态分布，性别、年龄组间差异较小（p < 0.05）。9.5%至16.6%的成年性别年龄组的SMC低于基于人群的参考区间的下限（0.75-0.955 mmol）。L-1)作为1971-1974年实施的NHANES I的一部分在美国人口中建立。患有糖尿病与0.04到0.07毫摩尔有关。L-1较低的SMC在各种模型中与没有糖尿病的人相比。体重指数、糖化血红蛋白、血清葡萄糖和胰岛素浓度以及胰岛素抵抗的稳态模型评估与SMC呈负相关。这是第一个在加拿大人口的全国代表性样本中报告SMCs的研究。与基于人群的参考区间相比，相当大比例的加拿大人是低镁血症，SMC与糖尿病、血糖控制和胰岛素抵抗指标呈负相关。
Total serum magnesium (Mg) concentration (SMC) is commonly used to assess Mg status. This study reports current SMCs of Canadians and their associations with demographic factors, diabetes, and measures of glycemic control and insulin resistance using results from the Canadian Health Measures Survey cycle 3 (2012-2013). Associations were examined in adults aged 20-79 years using linear mixed models. Mean SMCs and percentile distributions for 11 sex-age groups between 3 and 79 years (n = 5561) are reported. SMCs were normally distributed and differences (p < 0.05) among sex and age groups were small. Between 9.5% and 16.6% of adult sex-age groups had a SMC below the lower cut-off of a population-based reference interval (0.75-0.955 mmol.L-1) established in the United States population as part of the NHANES I conducted in 1971-1974. Having diabetes was associated with 0.04 to 0.07 mmol.L-1 lower SMC compared to not having diabetes in the various models. Body mass index, glycated hemoglobin, serum glucose and insulin concentrations, and homeostatic model assessment of insulin resistance were negatively associated with SMC. This is the first study to report SMCs in a nationally representative sample of the Canadian population. A substantial proportion of Canadians are hypomagnesaemic in relation to a population-based reference interval, and SMC was negatively associated with diabetes and indices of glycemic control and insulin resistance.