Acute effect of brisk walking with graduated compression stockings on vascular endothelial function and oxidative stress
Acute effect of brisk walking with graduated compression stockings on vascular endothelial function and oxidative stress
复制标题
渐进式压力袜快走对血管内皮功能和氧化应激的急性影响
DOI：
10.1111/cpf.12052
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Iwasaki T.
中科院分区：
文献类型：
--
作者：
Okamoto T;Sakamaki-Sunaga M;Min S;Miura T;Iwasaki T.
本研究的目的是探讨快速步行与不分级压缩袜（GCS）对血管内皮功能和氧化应激的急性影响。在一项随机交叉试验中，10名年轻健康受试者在有（GCS试验）和没有（CON试验）GCS的情况下轻快地行走30分钟。在两项试验中，使用B模式超声检查，在步行前和步行后30分钟，测量肱动脉血流介导的扩张（FMD），即每次FMD测量时，峰值直径相对于既往闭塞时基线值的百分比增加。在两项试验中，在步行前和步行后30分钟，还使用自由基选择性评估器测量了活性氧代谢产物衍生物（d-ROM）（作为活性氧产物的指标）和生物抗氧化潜力（BAP）（作为抗氧化潜力的指标）。快走后两组FMD均显著降低（P<0.05）。而快走后GCS组FMD明显高于CON组（P<0.05）。两项试验前后d-ROM均无变化，而GCS试验中行走后BAP显著增加（P<0.05）。这些研究结果表明，快步走，而穿着GCS抑制FMD的减少，并增加BAP。
The purpose of this study was to investigate the acute effect of brisk walking with and without graduated compression stockings (GCSs) on vascular endothelial function and oxidative stress. Ten young healthy subjects walked briskly for 30 min with (GCS trial) and without (CON trial) GCSs in a randomized crossover trial. Brachial artery flow‐mediated dilation (FMD) was measured as the per cent rise in the peak diameter from the baseline value at prior occlusion at each FMD measurement using B‐mode ultrasonography before and 30 min after walking in the two trials. Derivatives of reactive oxygen metabolites (d‐ROM), as an index of products of reactive oxygen species, and biological anti‐oxidant potential (BAP), as an index of anti‐oxidant potential, were also measured using a free radical elective evaluator before and 30 min after walking in both trials. FMD significantly decreased after brisk walking in both trials (P<0·05). However, FMD after brisk walking in the GCS trial was significantly higher than that in the CON trial (P<0·05). The d‐ROM did not change before and after both trials, whereas the BAP significantly increased after walking in the GCS trial (P<0·05). These findings demonstrate that brisk walking while wearing GCSs suppresses the decrease in FMD and increases BAP.