Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants
Multistep synthesis of amides from alcohols and amines in continuous flow microreactor systems using oxygen and urea hydrogen peroxide as oxidants
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DOI：
10.1039/c3gc40407b
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发表时间：
2013-01-01
期刊：
影响因子：
9.8
通讯作者：
Jensen, Klavs F.
中科院分区：
文献类型：
--
作者：
Liu, Xiaoying;Jensen, Klavs F.
通过将多相氧化、气液分离和氧化酰胺化反应整合为一个连续体系，证明了以醇和胺为起始原料，在温和条件下多步合成酰胺类化合物的方法。使用廉价的氧气和尿素过氧化氢作为唯一的氧化剂，为酰胺的合成提供了一条经济和适用的路线。
By integrating a heterogeneous oxidation step, gas-liquid separation, and an oxidative amidation reaction to form a continuous system, a multistep synthetic protocol has been demonstrated to produce amides under mild conditions using alcohols and amines as the starting materials. The use of inexpensive oxygen and urea hydrogen peroxide as the only oxidants affords an economical and adaptable synthetic route for amides.