C-H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments.
C-H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments.
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DOI：
10.1039/c8ob01025k
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发表时间：
2018-08
影响因子：
3.2
通讯作者：
M. Wegmann;Michael Henkel;T. Bach
中科院分区：
文献类型：
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作者：
M. Wegmann;Michael Henkel;T. Bach
Catellani 反应基于 Pd(0) 的氧化加成和降冰片烯的中间碳钯化实现邻位 C-H 活化。在其变体中，最近开发的吲哚 C2 选择性烷基化是特别的，因为它采用 Pd(ii) 作为钯源。这篇评论描述了这种转变的机制背景。阐述了全合成和生物相关分子合成中的应用，并讨论了该方法的进一步发展。
The Catellani reaction enables an ortho-C-H activation based on oxidative addition of Pd(0) and an intermediary carbopalladation of norbornene. Among its variants, the recently developed C2-selective alkylation of indoles is particular as it employs Pd(ii) as the source of palladium. This review describes the mechanistic background of this transformation. Applications in total synthesis and in the synthesis of biologically relevant molecules are illustrated and further developments of the method are discussed.