Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury.
Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury.
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DOI：
10.2174/156652412803833517
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发表时间：
2012-12
影响因子：
2.5
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Ma H;Sinha B;Pandya RS;Lin N;Popp AJ;Li J;Yao J;Wang X
有证据表明，人工降低体温和大脑温度可以显着减少新生儿和成人脑损伤的有害影响。虽然低温治疗的益处早已为人们所知并应用于临床，但其潜在的分子机制尚未阐明。缺氧缺血性脑损伤和创伤性脑损伤都引发了一系列的生化和分子事件，导致额外的脑损伤。诱导治疗性低温似乎改善了最终导致神经元损伤的分子级联反应。低温减弱了由初始损伤产生的毒性，初始损伤通常会产生活性氧、神经递质、炎症介质和细胞凋亡。已经在不同深度和水平的低温下进行实验以探索神经保护。本文综述了目前已知的治疗性低温在新生儿缺氧缺血性脑损伤和创伤性脑损伤实验模型中的有益作用，并探讨了可能成为新型治疗靶点的分子机制。此外，本文综述了低温治疗新生儿缺氧缺血性脑病和成人创伤性脑损伤的临床意义。
Evidence shows that artificially lowering body and brain temperature can significantly reduce the deleterious effects of brain injury in both newborns and adults. Although the benefits of therapeutic hypothermia have long been known and applied clinically, the underlying molecular mechanisms have yet to be elucidated. Hypoxic-ischemic brain injury and traumatic brain injury both trigger a series of biochemical and molecular events that cause additional brain insult. Induction of therapeutic hypothermia seems to ameliorate the molecular cascade that culminates in neuronal damage. Hypothermia attenuates the toxicity produced by the initial injury that would normally produce reactive oxygen species, neurotransmitters, inflammatory mediators, and apoptosis. Experiments have been performed on various depths and levels of hypothermia to explore neuroprotection. This review summarizes what is currently known about the beneficial effects of therapeutic hypothermia in experimental models of neonatal hypoxic-ischemic brain injury and traumatic brain injury, and explores the molecular mechanisms that could become the targets of novel therapies. In addition, this review summarizes the clinical implications of therapeutic hypothermia in newborn hypoxic-ischemic encephalopathy and adult traumatic brain injury.
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影响因子：
4.2
作者：
Clifton GL;Drever P;Valadka A;Zygun D;Okonkwo D
通讯作者：
Okonkwo D
影响因子：
48
作者：
Clifton, Guy L.;Valadka, Alex;Zygun, David;Coffey, Christopher S.;Drever, Pamala;Fourwinds, Sierra;Janis, L. Scott;Wilde, Elizabeth;Taylor, Pauline;Harshman, Kathy;Conley, Adam;Puccio, Ava;Levin, Harvey S.;McCauley, Stephen R.;Bucholz, Richard D.;Smith, Kenneth R.;Schmidt, John H.;Scott, James N.;Yonas, Howard;Okonkwo, David O.
通讯作者：
Okonkwo, David O.
DOI：
10.1136/adc.2008.146977
发表时间：
2009-07-01
影响因子：
4.4
作者：
Azzopardi, D.;Strohm, B.;Brocklehurst, P.
通讯作者：
Brocklehurst, P.
影响因子：
8.3
作者：
Dingley, J;Tooley, J;Thoresen, M
通讯作者：
Thoresen, M
影响因子：
158.5
作者：
Clifton, GL;Miller, ER;Schwartz, M
通讯作者：
Schwartz, M