Immunological approach to Ménière's disease: vestibular immune injury following immune reaction of the endolymphatic sac.
Immunological approach to Ménière's disease: vestibular immune injury following immune reaction of the endolymphatic sac.
复制标题
梅尼埃病的免疫学方法：内淋巴囊免疫反应后的前庭免疫损伤。
DOI：
10.1159/000276601
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Yagi
中科院分区：
文献类型：
--
作者：
S. Tomiyama;M. Nonaka;Y. Gotoh;T. Ikezono;T. Yagi
通过对豚鼠内淋巴囊（囊）进行直接抗原刺激，研究了热试验结果和自发性眼球震颤与前庭器官感觉上皮组织学改变和淋巴周围抗体水平的关系。在第二个锁孔帽贝血青素（KLH）挑战囊，刺激性眼球震颤，随后是麻痹性眼球震颤和抑制热量反应。这些结果与前庭器官感觉上皮的退化程度和淋巴周围抗体的水平密切相关。另一方面，磷酸盐缓冲盐水接种、对囊的原发性KLH攻击或对硬膜内间隙的继发性KLH攻击都不会导致前庭功能的紊乱。这些结果提示，胞囊的免疫应答可能是msamuise病发病的重要关键。
Following direct antigen challenge to the endolymphatic sac (sac), the relation of caloric test results and spontaneous nystagmus to the histological changes of the sensory epithelium of the vestibular organ and perilymph antibody levels was investigated in the guinea pig. In a secondary keyhole limpet hemocyanin (KLH) challenge to the sac, irritative nystagmus was followed by paralytic nystagmus and a suppression of caloric reaction. These findings correlated well with the degree of degeneration of the sensory epithelium of the vestibular organ and the levels of perilymph antibody. On the other hand, neither phosphate-buffered saline inoculation nor primary KLH challenge to the sac nor a secondary KLH challenge to the intradural space resulted in a disturbance of the vestibular function. These results suggest that the immune response of the sac may possibly be an important key to the pathogenesis of Ménière's disease.