SMAKing Ca2+ sparks in arterial myocytes.
SMAKing Ca2+ sparks in arterial myocytes.
复制标题
SMAKing Ca2 在动脉肌细胞中产生火花。
DOI：
10.1113/jphysiol.2007.143529
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Santana,LuisF
中科院分区：
文献类型：
--
作者：
Santana,LuisF
Physiology, Essin et al.(2007) examined the relationship between Cav1. 2 L-type Ca2+ channel function and Ca2+ spark activity in arterial myocytes. To do this, they took advantage of the SMAKO mouse (Moosmang et al. 2003)–a conditional, vascular smooth muscle-specific Cav1. 2 knock-out mouse. Using SMAKO mice they provide what represents the strongest, most direct demonstration that, in arterial myocytes, local Ca2+ signalling between Cav1. 2 channels and ryanodine receptors (RyRs) is not required for the activation of Ca2+ sparks. Rather, Cav1. 2 activity influences Ca2+ spark activity in a subtler, indirect way by controlling sarcoplasmic reticulum (SR) Ca2+ load. The functional implications of these findings are discussed below. Cav1. 2 is the predominant L-type Ca2+ channel isoform expressed in murine arterial smooth muscle (Moosmang et al.
