Organization of cell assemblies in the hippocampus
Organization of cell assemblies in the hippocampus
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DOI：
10.1038/nature01834
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发表时间：
2003-07-31
期刊：
影响因子：
64.8
通讯作者：
Buzsáki, G
中科院分区：
文献类型：
--
作者：
Harris, KD;Csicsvari, J;Buzsáki, G
神经元可以产生具有高时间精度的动作电位（1）。一个基本问题是信息处理中是否以及如何使用此功能。根据“细胞组装”假设，神经元的解剖学分布组的瞬时同步是外部感觉输入和内部认知机制的处理（2-4）。因此，应将神经元种群排列成，其同步超过了通过感觉输入通过常见调制所预测的组。在这里，我们发现，除了在太空中的动物位置外，还可以使用同时记录的神经元的尖峰时代，可以更准确地预测海马锥体细胞的尖峰时间。当空间预测通过空间依赖的theta相调制（5-8）进行完善时，这种改进仍保持不变。从同时同时活动中最好预测峰值时间的时间窗口为10-30 ms，这表明在此时间尺度上将细胞组件同步。因为这个时间窗口与锥体神经元的膜时间常数（9），海马伽马振荡的周期（10）和突触可塑性的时间窗口（11），我们建议在此时间尺度上进行此时间尺度的信息传输是最佳的。和在皮层电路中存储。
Neurons can produce action potentials with high temporal precision(1). A fundamental issue is whether, and how, this capability is used in information processing. According to the 'cell assembly' hypothesis, transient synchrony of anatomically distributed groups of neurons underlies processing of both external sensory input and internal cognitive mechanisms(2-4). Accordingly, neuron populations should be arranged into groups whose synchrony exceeds that predicted by common modulation by sensory input. Here we find that the spike times of hippocampal pyramidal cells can be predicted more accurately by using the spike times of simultaneously recorded neurons in addition to the animals location in space. This improvement remained when the spatial prediction was refined with a spatially dependent theta phase modulation(5-8). The time window in which spike times are best predicted from simultaneous peer activity is 10-30 ms, suggesting that cell assemblies are synchronized at this timescale. Because this temporal window matches the membrane time constant of pyramidal neurons(9), the period of the hippocampal gamma oscillation(10) and the time window for synaptic plasticity(11), we propose that cooperative activity at this timescale is optimal for information transmission and storage in cortical circuits.