A Moderate-Protein Diet Produces Sustained Weight Loss and Long-Term Changes in Body Composition and Blood Lipids in Obese Adults
A Moderate-Protein Diet Produces Sustained Weight Loss and Long-Term Changes in Body Composition and Blood Lipids in Obese Adults
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DOI：
10.3945/jn.108.099440
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发表时间：
2009-03-01
影响因子：
4.2
通讯作者：
Kris-Etherton, Penny
中科院分区：
文献类型：
--
作者：
Layman, Donald K.;Evans, Ellen M.;Kris-Etherton, Penny
增加蛋白质和减少碳水化合物的饮食（PRO）对减肥有效，但对维持体重的长期影响尚不清楚。这项研究比较了短期减肥（4 个月）和使用适度 PRO 饮食或传统高碳水化合物 (CHO) 饮食维持体重（8 个月）后体重、成分和血脂的变化。参与者（年龄 = 45.4 +/- 1.2 岁；BMI = 32.6 +/- 0.8 kg/m(2)；n = 130）被随机分配至 2 种能量限制饮食（-500 kcal/d 或 -2093 kJ/d）：PRO 含 1.6 g.kg(-1).d(-1) 蛋白质和 220 g/d 碳水化合物。 4 个月时，PRO 组比 CHO 组（-4.6 +/- 0.3 kg）多减少了 22% 的脂肪量（FM）（-5.6 +/- 0.4 kg），但组间体重减轻没有差异（-8.2 +/- 0.5 kg 与 -7.0 +/- 0.5 kg；P = 0.10）。 12 个月时，PRO 组有更多的参与者完成了研究（64% vs. 45%，P < 0.05），身体成分改善也更大；然而，体重减轻在各组之间没有差异（-10.4 +/- 1.2 kg 与 -8.4 +/- 0.9 kg；P = 0.18）。使用体重减轻>10%的参与者的依从性标准，与CHO A组相比，PRO组中有更多的参与者（31% vs. 21%）减轻了更多体重（-16.5 +/- 1.5 vs. -12.3 +/- 0.9 kg；P < 0.01）和FM（-11.7 +/- 1.0 vs. -7.9 +/- 0.7 kg；P < 0.01）。与 PRO 相比，CHO 饮食在 4 个月时降低了血清胆固醇和 LDL 胆固醇（P < 0.01），但这种效果在 12 个月时并未保持。与 CHO 相比，4 个月和 12 个月时，PRO 对血清三酰甘油 (TAG)、HDL 胆固醇 (HDL-C) 和 TAG:HDL-C 具有持续良好的影响（P < 0.01）。与 CHO 饮食相比，PRO 饮食在初始减肥和长期维持期间对 FM 减少和身体成分改善更有效，并且 TAG 持续减少，HDL-C 增加。 J.努特尔。 139：514-521，2009。
Diets with increased protein and reduced carbohydrates (PRO) are effective for weight loss, but the long-term effect on maintenance is unknown. This study compared changes in body weight and composition and blood lipids after short-term weight loss (4 mo) followed by weight maintenance (8 mo) using moderate PRO or conventional high-carbohydrate (CHO) diets. Participants (age = 45.4 +/- 1.2 y; BMI = 32.6 +/- 0.8 kg/m(2); n = 130) were randomized to 2 energy-restricted diets (-500 kcal/d or -2093 kJ/d): PRO with 1.6 g.kg(-1).d(-1) protein and 220 g/d carbohydrates. At 4 mo, the PRO group had lost 22% more fat mass (FM) (-5.6 +/- 0.4 kg) than the CHO group (-4.6 +/- 0.3 kg) but weight loss did not differ between groups (-8.2 +/- 0.5 kg vs. -7.0 +/- 0.5 kg; P = 0.10). At 12 mo, the PRO group had more participants complete the study (64 vs. 45%, P < 0.05) with greater improvement in body composition; however, weight loss did not differ between groups (-10.4 +/- 1.2 kg vs. -8.4 +/- 0.9 kg; P = 0.18). Using a compliance criterion of participants attaining >10% weight loss, the PRO group had more participants (31 vs. 21 %) lose more weight (-16.5 +/- 1.5 vs. -12.3 +/- 0.9 kg; P < 0.01) and FM (-11.7 +/- 1.0 vs. -7.9 +/- 0.7 kg; P < 0.01) than the CHO A group. The CHO diet reduced serum cholesterol and LDL cholesterol compared with PRO (P < 0.01) at 4 mo, but the effect did not remain at 12 mo. PRO had sustained favorable effects on serum triacylglycerol (TAG), HDL cholesterol (HDL-C), and TAG:HDL-C compared with CHO at 4 and 12 mo (P < 0.01). The PRO diet was more effective for FM loss and body composition improvement during initial weight loss and long-term maintenance and produced sustained reductions in TAG and increases in HDL-C compared with the CHO diet. J. Nutr. 139: 514-521, 2009.