Cancer treatment during the coronavirus disease 2019 pandemic: Do not postpone, do it!
Cancer treatment during the coronavirus disease 2019 pandemic: Do not postpone, do it!
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DOI：
10.1016/j.ejca.2020.04.034
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发表时间：
2020-07-01
影响因子：
8.4
通讯作者：
Piacentini, Federico
中科院分区：
文献类型：
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作者：
Omarini, Claudia;Maur, Michela;Piacentini, Federico
2020年1月底，一种名为严重急性呼吸综合征冠状病毒2的新型贝塔冠状病毒在意大利逐步传播。癌症患者被认为更容易感染，因为恶性肿瘤和抗癌治疗都会导致免疫抑制。从意大利政府的第一项限制措施(2月23日)开始，摩德纳癌症中心采纳了实用的健康警戒建议，在不忽视癌症管理的情况下将接触病毒的风险降至最低。从2020年2月23日至3月31日，1257例肿瘤或血液系统恶性肿瘤患者接受了积极的抗癌治疗。所有工作人员的活动都根据我们的实际冠状病毒病2019年(新冠肺炎)指南重新安排。在此期间，我们记录了9例新冠肺炎感染(0.71%)在癌症患者和3例(1.66%)卫生工作者。我们癌症患者的死亡率为22%，与文献报道的数据一致。总之，遵循我们的实际健康警示建议，医生应该有信心维持挽救生命的抗癌治疗，而不会过度增加医院内新冠肺炎感染的风险。高死亡率表明，所有接受积极抗癌治疗并出现流感样症状的患者都必须仔细筛查是否有新冠肺炎感染。(C)2020爱思唯尔有限公司。保留所有权利。
At the end of January 2020, a novel betacoronavirus, known as severe acute respiratory syndrome coronavirus 2, progressively spread in Italy. Patients with cancer are considered more prone to infections because of the immunosuppressive status due to both malignancy and anticancer treatments. From the first Italian government restrictions (23rd February), Modena Cancer Center adopted practical health vigilance recommendations to minimise the risk of exposure to the virus without overlooking cancer management. From 23rd February to 31st March 2020, 1257 patients on active anticancer treatment for oncological or haematological malignancies attended our institution. All the staff activities were rescheduled following our practical coronavirus disease 2019 (COVID-19) guideline. During this period, we have tallied 9 cases of COVID-19 infection (0.71%) in patients with cancer and 3 cases (1.66%) in health workers. The mortality rate of our patients with cancer was 22%, consistent with the data reported in the literature. In conclusion, following our practical health vigilance recommendations, physicians should be confident in maintaining life-saving anticancer treatment without exceedingly increasing the risk of nosocomial COVID-19 infection. The high rate of mortality suggested that all patients on active anticancer treatment with flu-like symptoms have to be carefully screened for COVID-19 infection. (C) 2020 Elsevier Ltd. All rights reserved.