ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischemia/reperfusion injury
ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischemia/reperfusion injury
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ADAMTS13 抑制氧化应激并改善缺血/再灌注损伤后的进行性慢性肾病
DOI：
10.1111/apha.13586
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发表时间：
2020
影响因子：
6.3
通讯作者：
En Yin Lai
中科院分区：
文献类型：
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作者：
Suhan Zhou;Jie Guo;Liang Zhao;Yixin Liao;Qin Zhou;Yu Cui;Weipeng Hu;Jianghua Chen;Xiaoqiu Ren;Qichun Wei;Shan Jiang;Yali Zheng;Lingli Li;Christopher S. Wilcox;Pontus B. Persson;Andreas Patzak;Jiong Tian;En Yin Lai
在肾脏疾病中观察到具有血小板反应蛋白1型motif成员13 （ADAMTS13）的A崩解素和金属蛋白酶水平降低。我们测试了重组人ADAMTS13 （rhADAMTS13）是否减轻慢性肾脏疾病（CKD）的肾损伤及其潜在机制。
Reduced A Disintegrin And Metalloproteinase with a ThromboSpondin type 1 motif member 13 (ADAMTS13) levels are observed in kidney disease. We test whether recombinant human ADAMTS13 (rhADAMTS13) mitigates renal injury in chronic kidney disease (CKD) and the potential mechanisms.