Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains
Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains
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DOI：
10.1086/592051
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发表时间：
2008-10-15
影响因子：
6.4
通讯作者：
Novick, Richard P.
中科院分区：
文献类型：
--
作者：
Shopsin, Bo;Drlica-Wagner, Alex;Novick, Richard P.
在金黄色葡萄球菌感染过程中，葡萄球菌毒力调节基因agr经常发生突变。agr缺陷型菌株是否适合定植，这是感染的一个重要先决条件，目前尚不清楚。通过检测δ-溶血素活性和agr自诱导肽产生的测定进行的筛选表明，160名健康人受试者中有15名（约9%）被agr缺陷型菌株或agr阳性和agr缺陷型菌株的混合物定殖。金黄色葡萄球菌在家族成员中存在相同的agr缺陷型菌株，表明这些菌株是可传播的。此外，携带agr缺陷型菌株与住院治疗有关，提高了在医院环境中选择此类菌株的可能性。
Mutations in the staphylococcal virulence regulator gene agr frequently occur during Staphylococcus aureus infection. Whether agr-defective strains are fit for colonization, an important prerequisite for infection, is unknown. Screening by means of assays to detect delta-hemolysin activity and agr autoinducing peptide production indicated that 15 (similar to 9%) of 160 healthy human subjects were colonized with an agr-defective strain or a mixture of agr-positive and -defective S. aureus strains. The presence of identical agr-defective strains in family members suggests that these strains are transmissible. Additionally, carriage of an agr-defective strain was associated with hospitalization, raising the possibility that such strains may be selected in a nosocomial setting.