Dietary Vitamin E Intake Is Associated With a Reduced Risk of Developing Digestive Diseases and Nonalcoholic Fatty Liver Disease.
Dietary Vitamin E Intake Is Associated With a Reduced Risk of Developing Digestive Diseases and Nonalcoholic Fatty Liver Disease.
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DOI：
10.14309/ajg.0000000000001726
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发表时间：
2022-06-01
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维生素E补充剂被推荐用于治疗非糖尿病患者的非酒精性脂肪肝（NAFLD），但其预防作用尚不清楚。我们评估了膳食维生素E摄入与疾病表型，并评估了维生素E水平与NAFLD的发展。来自> 210，000名参与者的数据表明，增加膳食维生素E与几种胃肠道疾病的发病率降低和总体死亡率降低有关。维生素E摄入量增加的糖尿病和超重受试者的NAFLD诊断较少。我们的研究结果揭示了维生素E消耗与几种胃肠道疾病的相关性，并保证进一步的机制和治疗研究。
Vitamin E supplementation is recommended for the treatment of non-alcoholic fatty liver disease (NAFLD) for nondiabetic patients, but its preventative effects are unclear. We assessed dietary Vitamin E intake with disease phenotypes and evaluated Vitamin E levels with the development of NAFLD. Data from >210,000 participants demonstrate that increased dietary Vitamin E associates with reduced rates of several gastrointestinal diseases and reduced overall mortality. Diabetic and overweight subjects with increased Vitamin E intake have fewer NAFLD diagnoses. Our findings reveal the relevance of Vitamin E consumption for several gastrointestinal diseases and warrant further mechanistic and therapeutic investigations.