Power output of fast and slow skeletal muscles of mdx (dystrophic) and control mice after clenbuterol treatment
Power output of fast and slow skeletal muscles of mdx (dystrophic) and control mice after clenbuterol treatment
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DOI：
10.1111/j.1469-445x.2000.02018.x
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发表时间：
2000-05-01
影响因子：
2.7
通讯作者：
Faulkner, JA
中科院分区：
文献类型：
--
作者：
Lynch, GS;Hinkle, RT;Faulkner, JA
MDX小鼠是杜氏肌营养不良症最常用的动物模型。我们检验了零假设，即20周的克伦特罗治疗(类似于2 mg kg(-1)天(-1))的MDX和对照组小鼠不会对指长伸肌(EDL)和比目鱼肌的绝对力量和比例力(P-o，kNm(-2))以及绝对和标准化功率输出(W kg(-1))产生影响。对于MDX和对照组小鼠，瘦肉精治疗使两块肌肉的质量略有增加，但没有增加绝对或比力，也没有增加正常化的功率输出。在绝对功率输出方面，只有MDX小鼠的EDL肌肉在治疗后表现出差异，治疗组小鼠的功率输出是未治疗组的118%。克伦特罗治疗对骨骼肌动态特性的影响不大，对于营养不良条件下肌肉功能的任何改善几乎没有支持。
The mdx mouse is the most commonly used animal model for Duchenne muscular dystrophy. We tested the null hypothesis that 20 weeks of clenbuterol treatment (similar to 2 mg kg(-1) day(-1)) of mdx and control mice would have no effect on the absolute and specific force (P-o, kN m(-2)) and absolute and normalised power output (W kg(-1)) of extensor digitorum longus (EDL) and soleus muscles. For mdx and control mice, clenbuterol treatment produced modest increases in the mass of the two muscles but did not increase absolute or specific force or normalised power output. For absolute power output, only the EDL muscles of mdx mice showed a difference following treatment, with the power output of treated mice being 118% that of the untreated mice. The modest effects of clenbuterol treatment on the dynamic properties of skeletal muscle provide little support for any improvement in muscle function for the dystrophic condition.