Lethal effect of aclacinomycin A on cultured mouse L cells.
Lethal effect of aclacinomycin A on cultured mouse L cells.
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阿克拉霉素 A 对培养的小鼠 L 细胞的致死作用。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
T. Terasima
中科院分区：
文献类型：
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作者：
M. Tanabe;T. Miyamoto;Y. Nakajima;T. Terasima
研究了阿克拉霉素 A 对培养的小鼠 L 细胞存活的影响。该药物表现出特征性的剂量-生存反应，即最初的指数反应，随后是以宽肩为特征的 S 形失活。随着暴露时间的延长，在低浓度下观察到的指数响应随着肩宽的逐渐减小而显着增强。两次剂量的分数生存研究表明，肩部区域的至少一部分与亚致死损伤的积累有关，这些损伤可以在第一次剂量后 12 小时内修复。讨论了这些结果对治疗安排的影响。
The effect of aclacinomycin A on the survival of cultured mouse L cells was studied. The drug showed a characteristic dose-survival response, i.e., an initial exponential responses followed by a sigmoidal inactivation characterized by a broad shoulder. With prolongation of the exposure time, the exponential response seen at a low concentration was remarkably intensified with a progressive decrease of the shoulder width. Two-dose fractional survival studies revealed that at least a portion of the shoulder region relation to an accumulation of sublethal damage which can be repaired during 12 hr after the first dose. The implication of these results for therapeutic scheduling is discussed.