[Biological behavior of hypopharyngeal carcinoma].
[Biological behavior of hypopharyngeal carcinoma].
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下咽癌的生物学行为[J].
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
L. Zhou
中科院分区：
文献类型：
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作者：
L. Zhou
下咽鳞状细胞癌（HPC）预后极差。包括HPC在内的头颈部鳞状细胞癌细胞系的特征通过各种方法进行了研究，例如，化疗敏感性试验和免疫组化染色方法，以确定这种不良预后是否是由于这种癌症的生物学行为。发现HPC细胞系对抗肿瘤药物具有抗性，即，HPC细胞对热处理有一定的耐受性，细胞间粘附分子-1表达较弱。低浓度EGF刺激可诱导HPC细胞系的DNA合成，并且这些HPC细胞上的EGFR含量非常高。此外，在HPC细胞系中发现cyclinD 1过表达。基于上述发现，进一步分析下咽癌细胞和发展一种新的治疗模式，以控制肿瘤生长和转移因素影响的不良结果是必要的，以改善这种癌症的预后。
Hypopharyngeal squamous cell carcinomas (HPC) has an extremely poor prognosis. Characteristics of cell lines of head and neck squamous cell carcinomas including HPC were studied by various methods, e.g., chemosensitivity test and the immunohistochemistry staining method, to determine whether this poor prognosis is due to the biological behavior of this cancer. An HPC cell line was found to be resistant to anti tumor drugs, i.e., PEP, MTX and CPM and moderately sensitive to CDDP, 5-FU and ADM. Thermoresistance to hyperthermatic treatment and weak expression of ICAM-1 on the HPC cell line were observed. DNA synthesis by the HPC cell line was induced by stimulation with a low concentration of EGF and the amount of EGFR on these HPC cells was very high. In addition, cyclinD1 overexpression was found in the HPC cell line. Based on the above findings, further analysis of hypopharyngeal carcinoma cells and the development of a new treatment modality to control tumor growth and metastatic factors influencing the poor outcome are necessary to improve the prognosis of this cancer.
从头颈鳞状癌建立的人细胞系中表皮生长因子受体蛋白酪氨酸激酶活性。
影响因子：
11.2
作者：
Maxwell,SA;Sacks,PG;Gutterman,JU;Gallick,GE
通讯作者：
Gallick,GE
影响因子：
4
作者：
MOTOKURA, T;ARNOLD, A
通讯作者：
ARNOLD, A