1)Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection.
1)Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection.
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1)糖蛋白B的胞质尾部结构域对于HHV-6感染至关重要。
DOI：
10.1016/j.virol.2015.12.018
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Mori Y.
中科院分区：
文献类型：
--
作者：
Mahmoud NF;Jasirwan C;Kanemoto S;Wakata A;Wang B;Hata Y;Nagamata S;Kawabata A;Tang H;Mori Y.
人疱疹病毒6型（HHV-6）糖蛋白B（gB）是一种在疱疹病毒中高度保守的病毒糖蛋白，是病毒侵入和细胞融合所必需的。本研究探讨了HHV-6 gB胞质尾区（CTD）的功能。构建了一种gB CTD缺失突变体，与其回复突变体相反，该突变体不能重建。此外，gB胞质尾的缺失损害了gB蛋白的胞内转运到trans-Golgi网络（TGN）。综上所述，这些结果表明，gB CTD是HHV-6传播的关键和重要的细胞内运输。
Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to thetrans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.