Similar acid stimulatory potencies of synthetic human big and little gastrins in man.
Similar acid stimulatory potencies of synthetic human big and little gastrins in man.
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合成人类大胃泌素和小胃泌素对人体的酸刺激效力相似。
DOI：
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发表时间：
1984
影响因子：
15.9
通讯作者：
J. Walsh
中科院分区：
文献类型：
--
作者：
V. Eysselein;V. Maxwell;T. Reedy;E. Wünsch;J. Walsh
根据修改后的结构制备的新合成的人大胃泌素 (G34)，其氧化蛋氨酸残基含量低于 3%，与合成的人小胃泌素 (G17) 在人类受试者中的酸刺激活性和清除率进行了比较。延长输注每种类型的胃泌素表明，G34 达到稳定血浆浓度所需的时间比 G17 长得多。血浆胃泌素浓度的时间过程可以通过一室模型来描述，G34的半衰期为44分钟，G17的半衰期为8分钟。快速静脉输注后，G34 产生的总酸反应比等摩尔剂量的 G17 大得多，并且该反应与积分血浆胃泌素增量成正比。在G34和G17长时间静脉输注的第三个小时内，产生相同血药浓度胃泌素所需的G34外源剂量仅为G17的四分之一。 G34 和 G17 的等效血液浓度与相似的酸分泌率相关。这些结果表明，G34 比人们想象的更有效，它具有与 G17 相似的活性，并且在估计循环胃泌素的总酸刺激活性时不能忽视它。总羧基末端免疫反应性胃泌素的测量可以很好地估计总酸刺激活性。
A newly synthesized human big gastrin (G34) that was prepared according to the revised structure and that contained less than 3% oxidized methionine residues was compared with synthetic human little gastrin (G17) for acid-stimulating activity and clearance in human subjects. Prolonged infusions of each type of gastrin revealed that the time required to approach stable plasma concentrations was much longer for G34 than for G17. The time course of plasma gastrin concentration could be described by one-compartment models with half-lives of 44 min for G34 and 8 min for G17. After rapid intravenous infusion, G34 produced a much larger total acid response than did an equimolar dose of G17, and the responses were directly proportional to the integrated plasma gastrin increments. During the third hour of prolonged intravenous infusions of G34 and G17, the exogenous dosage of G34 required to produce the same blood concentration of gastrin was only one-fourth that of G17. Equivalent blood concentrations of G34 and G17 were associated with similar rates of acid secretion. These results suggest that G34 is more potent than has been thought, that it has an activity similar to that of G17 and that it must not be ignored in estimating total acid-stimulating activity of circulating gastrins. The measurement of total carboxyl-terminal immunoreactive gastrin can produce a good estimate of total acid-stimulating activity.
有证据表明胃泌素 34 优先从人类十二指肠释放。
影响因子：
29.4
作者：
Lamers,CB;Walsh,JH;Jansen,JB;Harrison,AR;Ippoliti,AF;vanTongere,JH
通讯作者：
vanTongere,JH
人血浆中的胆囊收缩素八肽样免疫反应性。
影响因子：
29.4
作者：
Walsh,JH;Lamers,CB;Valenzuela,JE
通讯作者：
Valenzuela,JE
人下食管括约肌对合成人胃泌素 34 (G-34) 和 17 (G-17) 的反应。
影响因子：
29.4
作者：
Jensen,DM;McCallum,RW;Corazziari,E;Elashoff,J;Walsh,JH
通讯作者：
Walsh,JH