Daily Glucose Profiles in Japanese People with Normal Glucose Tolerance as Assessed by Continuous Glucose Monitoring
Daily Glucose Profiles in Japanese People with Normal Glucose Tolerance as Assessed by Continuous Glucose Monitoring
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DOI：
10.1089/dia.2008.0083
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发表时间：
2009-07-01
影响因子：
5.4
通讯作者：
Tajima, Naoko
中科院分区：
文献类型：
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作者：
Tsujino, Daisuke;Nishimura, Rimei;Tajima, Naoko
背景：关于日本糖耐量正常（NGT）人群餐后状态以及口服葡萄糖耐量试验（OGTT）期间的血糖波动情况，目前可获取的信息较少。
方法：通过使用持续血糖监测仪对27名日本受试者进行了4天的血糖监测。在第2天进行75克OGTT，纳入了经75克OGTT诊断为NGT的24名受试者。在第3天监测受试者日常生活中的餐后血糖情况。
结果：我们的研究结果显示，OGTT中血糖达到最高水平的中位时间（四分位间距）为葡萄糖负荷后38（25 - 49）分钟，早餐、午餐和晚餐后血糖达到最高水平的中位时间分别为40（31 - 75）、50（30 - 70）和45（36 - 50）分钟。OGTT期间血糖升高的中位数为45（35 - 66）毫克/分升，早餐、午餐和晚餐后的血糖升高中位数分别为21（12 - 32）、37（27 - 48）和44（25 - 63）毫克/分升。胰岛素生成指数较高的受试者血糖达到最高水平的时间较短（r = -0.46，P = 0.025），且在OGTT期间血糖升高幅度较小（r = 0.49，P = 0.014）。
结论：本研究是首次报道亚洲NGT人群血糖情况的报告。
Background: Little information is available regarding glucose fluctuations in postprandial states and during the oral glucose tolerance test (OGTT) in Japanese people with normal glucose tolerance (NGT).Methods: Glucose profiles of 27 Japanese people were measured for 4 days by using continuous glucose monitoring. A 75-g OGTT was conducted on the second day, and 24 subjects diagnosed with NGT by a 75-g OGTT were enrolled. The subjects were monitored for their postprandial glucose profile in their ordinary daily life on the third day.Results: The results of our study have shown that the median time (interquartile range) to maximum glucose levels in OGTT was 38 (25-49) min after glucose load and that the median time to maximum glucose levels after breakfast, lunch, and dinner was 40 (31-75), 50 (30-70), and 45 (36-50) min, respectively. The median increase in glucose during OGTT was 45 (35-66) mg/dL, and that after breakfast, lunch and dinner was 21 (12-32), 37 (27-48), and 44 (25-63) mg/dL, respectively. Those with a higher insulinogenic index reached their maximum glucose levels in a shorter time (r = -0.46, P = 0.025) and had smaller glucose increments during OGTT (r = 0.49, P = 0.014).Conclusions: This study is the first report to document the glucose profile of Asian people with NGT.