Ultraviolet radiation and incidence of cataracts in a nationwide US cohort
Ultraviolet radiation and incidence of cataracts in a nationwide US cohort
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DOI：
10.1080/09286586.2018.1501077
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发表时间：
2018-01-01
影响因子：
1.8
通讯作者：
Cahoon, Elizabeth K.
中科院分区：
文献类型：
--
作者：
Delavar, Arash;Freedman, D. Michal;Cahoon, Elizabeth K.
目的：我们通过测量紫外线辐射(UVR)暴露和对紫外线敏感度的测量来评估白内障和白内障手术的风险。方法：来自美国放射技术师研究的参与者从基线调查的年龄(2003-2005年)到白内障诊断、白内障手术或完成上一次调查(2012-2013年)的最早年龄。与UVR相关的因素包括与终身居住有关的卫星环境UVR、不同年龄段的户外活动时间、起泡晒伤病史、先前诊断的角质形成细胞癌以及虹膜颜色。我们使用以年龄为时间尺度的COX比例风险模型来计算白内障和白内障手术的风险比(HR)和95%可信区间(CI)。结果：参与者的入院年龄中位数为54.0岁，其中80.0%是女性，95.7%是白人。在44,891名符合条件的参与者中，报告了9399例白内障和3826例白内障手术。环境UVR(五分之一比1)与白内障(HR=1.08；95%CI：1.01-1.16)和白内障手术(HR=1.16；95%CI：1.05-1.29)的风险增加相关。终身平均户外活动时间与白内障风险无关。15岁之前和之后有起泡性晒伤的病史，但之前没有诊断出角质形成细胞癌与白内障和白内障手术有关。结论：我们的结果表明，在美国室内工作人员中，居住环境中的UVR和白内障风险的作用不大。
Purpose: We examine the risk of cataract and cataract surgery with measures of ultraviolet radiation (UVR) exposure and UVR sensitivity in a large, nationwide population of indoor workers.Methods: Participants from the US Radiologic Technologists Study were followed from age at baseline survey (2003-2005) to age at earliest of cataract diagnosis, cataract surgery, or completion of last survey (2012-2013). UVR-related factors included satellite-based ambient UVR linked to lifetime residences, time spent outdoors across various age periods, history of blistering sunburns, prior diagnosis of keratinocyte carcinoma, and iris color. We used Cox proportional hazards models with age as timescale to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for cataract and cataract surgery.Results: Participants had a median age of entry of 54.0years, were 80.0% female, and 95.7% white. Of the 44,891 eligible participants, 9399 cases of cataract and 3826 cases of cataract surgery were reported. Ambient UVR (quintile 5 vs. 1) was associated with an increased risk of cataract (HR = 1.08; 95% CI: 1.01-1.16) and cataract surgery (HR = 1.16; 95% CI: 1.05-1.29). Lifetime average time spent outdoors was not associated with cataract risk. History of blistering sunburns before and after age 15, but not previous keratinocyte carcinoma diagnosis was associated with both cataract and cataract surgery.Conclusion: Our results suggest a modest role for residence-based ambient UVR and cataract risk among indoor workers in the United States.