Organic Electrochemical Transistor with Molecularly Imprinted Polymer-Modified Gate for the Real-Time Selective Detection of Dopamine
Organic Electrochemical Transistor with Molecularly Imprinted Polymer-Modified Gate for the Real-Time Selective Detection of Dopamine
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DOI：
10.1021/acsapm.1c01563
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发表时间：
2022-03
影响因子：
5
通讯作者：
Kan Tang;Chyanne Turner;Leah Case;Amin Mehrehjedy;Xuyang He;W. Miao;Song Guo
中科院分区：
文献类型：
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作者：
Kan Tang;Chyanne Turner;Leah Case;Amin Mehrehjedy;Xuyang He;W. Miao;Song Guo
由于其低工作电压、高跨导和良好的水相容性，有机电化学晶体管（OECT）已广泛应用于氧化还原活性小分子（如多巴胺）的传感。然而，多巴胺 (DA) 的选择性检测可能具有挑战性，因为其传感机制依赖于栅极氧化还原化学引起的栅极电压偏移。为了引入多巴胺检测的选择性，以多巴胺作为模板，将聚吡咯薄膜电化学沉积在 Pt 栅电极上，然后在碱性溶液中过度氧化。与具有裸 Pt 栅极的器件相比，所得具有过氧化 MIP (o-MIP/Pt) 栅极的 OECT 传感器显示出类似的检测限，约为 34 nM。同时，与代表性干扰物抗坏血酸（AA）的漏极电流响应相比，在〜0.4至〜10μM的浓度范围内可以实现大于5的DA/AA信号比的良好选择性，而具有裸Pt栅极的OECT传感器对DA几乎没有选择性。无论添加顺序如何，OECT 传感器对 DA 的选择性可以在 1 倍 DA (∼0.4 μM) 和 10 倍 AA (∼4 μM) 共存时保持。
Because of their low operation voltage, high transconductance, and good aqueous compatibility, organic electrochemical transistors (OECTs) have been widely applied in the sensing of small redox-active molecules such as dopamine. However, selective detection of dopamine (DA) can be challenging since its sensing mechanism relies on the gate voltage offset caused by the redox chemistry at the gate electrode. To introduce selectivity toward dopamine detection, a polypyrrole film was electrochemically deposited on the Pt gate electrode with the presence of dopamine as a template and then overoxidized in an alkaline solution. The resultant OECT sensor with an overoxidized MIP (o-MIP/Pt) gate shows a similar detection limit of ∼34 nM as compared to the device with a bare Pt gate. At the same time, when compared to the drain current response of a representative interferent, ascorbate (AA), a good selectivity of DA/AA signal ratio of larger than 5 can be achieved in the concentration range between ∼0.4 and ∼10 μM, whereas OECT sensor with bare Pt gate shows little selectivity toward DA. The selectivity of the OECT sensor toward DA can be maintained in the copresence of 1-fold DA (∼0.4 μM) and 10-fold AA (∼4 μM), regardless of the order of the additions.