Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease.
Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for coronary artery disease.
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DOI：
10.1016/j.metabol.2003.10.016
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发表时间：
2004-03
期刊：
影响因子：
--
通讯作者：
J. Wegge;C. Roberts;T. Ngo;R. Barnard
中科院分区：
文献类型：
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作者：
J. Wegge;C. Roberts;T. Ngo;R. Barnard
炎症和单核细胞向动脉壁的募集被认为是动脉粥样硬化发生和发展的重要方面。本研究旨在研究严格的饮食和运动干预对血脂和炎症及循环粘附分子的影响。20名有冠心病（CAD）风险的绝经后妇女接受高纤维、低脂肪饮食，随意提供食物，并进行每日有氧运动，主要是步行。分别于干预前后抽取空腹血，检测血脂、胰岛素、血糖、C-反应蛋白（CRP）、血清淀粉样蛋白A（SAA）、白细胞介素-6（IL-6）、可溶性细胞间粘附分子（sICAM-1）和可溶性血管间粘附分子（sVCAM-1）。2周后，体重指数（BMI）（P <0.001）、血糖（P <0.05）、胰岛素（P <0.01）、所有血脂和总胆固醇（total-C）：高密度脂蛋白胆固醇（HDL-C）（P <0.01）显著降低。胰岛素抵抗（HOMA-IR）（P <0.01）、CRP（P <0.01）、SAA（P <0.01）和sICAM-1（P <0.05）的稳态模型评估值均降低，定量胰岛素敏感性检查指数升高（P <0.05）。在5名未使用激素替代疗法（HRT）的妇女中也发现了减少。IL-6或sVCAM-1在干预后没有显著降低。总的来说，这种干预措施改善了代谢和脂质状况，减少了炎症和细胞粘附分子在绝经后妇女在没有热量限制。快速改善可能降低急性心肌梗死（MI）的风险，如果持续，这些变化可能减轻动脉粥样硬化进展及其临床后果的风险。
Inflammation and the recruitment of monocytes into the artery wall are thought to be important aspects in the initiation and progression of atherosclerosis. The present study was designed to examine the effects of a rigorous diet and exercise intervention on plasma lipids and inflammatory and circulating adhesion molecules. Twenty postmenopausal women at risk for coronary artery disease (CAD) were placed on a high-fiber, low-fat diet, where food was provided ad libitum and daily aerobic exercise, primarily walking, was performed. In each subject, pre- and postintervention fasting blood was drawn for serum lipid, insulin, glucose, C-reactive protein (CRP), serum amyloid A (SAA), interleukin-6 (IL-6) and both soluble (s) intracellular and vascular adhesion molecule (sICAM-1 and sVCAM-1) were measured. After 2 weeks, significant reductions in body mass index (BMI) (P < .001), glucose (P < .05), insulin (P < .01), all serum lipids, and total cholesterol (total-C):high-density lipoprotein-cholesterol (HDL-C) (P < .01). Reductions in homeostasis model assessment for insulin resistance (HOMA-IR) (P < .01), CRP (P < .01), SAA (P < .01) and sICAM-1 (P < .05) were noted, as well as an increase in the quantitative insulin sensitivity check index (P < .05). Reductions were also noted in 5 women not using hormone replacement therapy (HRT). No significant reductions were found in IL-6 or sVCAM-1 in response to the intervention. Overall, this intervention resulted in improved metabolic and lipid profiles, reduced inflammatory, and cell adhesion molecules in postmenopausal women in the absence of caloric restriction. The rapid improvements may reduce the risk of acute myocardial infarction (MI), and if sustained, these changes may mitigate the risk for atherosclerosis progression and its clinical consequences.