Performance limits of nanobiosensors

Performance limits of nanobiosensors
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DOI:
10.1063/1.2211310
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发表时间:
2006-06-05
影响因子:
4
通讯作者:
Alam, M. A.
Alam, M. A.
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Nair, P. R.;Alam, M. A.

文献摘要

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一个简单的分析模型,反应扩散理论的基础上,开发预测的平均响应(沉降)时间(t(s))和最小可检测浓度(rho(0))的纳米生物传感器和纳米化学传感器之间的权衡。该模型预测了类似于k(D)的缩放关系rho(0)t(s)(MD),其中M-D和k(D)是一维、二维和三维纳米传感器的维度相关常数。我们探索使用这个分析模型的纳米传感器的性能限制,并支持其结论,使用详细的数值模拟。我们的研究结果有明显的和显着的影响,在文献中报道的分析物密度和响应时间和纳米生物传感器和纳米化学传感器的设计考虑。(c)2006年,美国物理学会。
A simple analytical model, based on reaction-diffusion theory, is developed to predict the trade-off between average response (settling) time (t(s)) and minimum detectable concentration (rho(0)) for nanobiosensors and nanochemical sensors. The model predicts a scaling relationship rho(0)t(s)(MD)similar to k(D), where M-D and k(D) are dimensionality dependent constants for one, two, and three dimensional nanosensors. We explore the performance limits of nanosensors using this analytical model and support its conclusions using detailed numerical simulation. Our results have obvious and significant implications for analyte density and response time reported in the literature and for design consideration of nanobiosensors and nanochemical sensors. (c) 2006 American Institute of Physics.