Elevated Th17 cells are associated with cardiovascular complications in ankylosing spondylitis
Elevated Th17 cells are associated with cardiovascular complications in ankylosing spondylitis
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DOI：
10.1093/rheumatology/keab888
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发表时间：
2021-12-11
期刊：
影响因子：
5.5
通讯作者：
Wang, Caihong
中科院分区：
文献类型：
--
作者：
Ding, Tingting;Li, Baochen;Wang, Caihong
目的强直性脊柱炎(AS)患者心血管疾病(CVD)负担加重，但其发病特点尚不清楚。本研究旨在探讨AS合并心血管疾病(AS-CVD)患者外周血中淋巴细胞和CD_4~+T细胞的百分率和绝对数，并探讨循环辅助性T细胞17(Th17)是否与AS心血管疾病的发生发展有关。方法对117例AS患者(46例有CVD，71例无CVD)进行回顾性研究。用流式细胞仪检测淋巴细胞和CD4+T细胞的百分率和绝对数。用Logistic回归分析心血管疾病与临床指标的关系。结果AS-CVD组Th17/Treg细胞比值(0.30vs0.19，P=0.014)和Th17细胞绝对数(7.27个/亩L vs4.34个/亩L，P<0.001)明显高于AS-NO-CVD组。多因素Logistic回归分析显示，Th1 7细胞升高(OR=1.2 0，P=0.016)与AS的心血管并发症有关。受试者工作特征(ROC)曲线显示Th17细胞对鉴别CVD有贡献，ROC曲线下面积(AUC)为0.729(95%CI：0.632，0.825，P<0.001)。结论我们的研究结果为Th17细胞与AS心血管风险增加之间的关联提供了证据。Th17细胞可能参与AS动脉粥样硬化的加速形成和心血管负荷的增加，对AS-CVD的早期评估和治疗有价值。
Objective Patients with ankylosing spondylitis (AS) carry an increased burden of cardiovascular diseases (CVD), but features denoting the development of CVD in AS are unclear. This study aimed to evaluate the percentage and absolute number of lymphocytes and CD4+T cells in AS patients complicated with CVD (AS-CVD) and determine whether circulating T helper 17 (Th17) cells are associated with the development of CVD in AS. Method A total of 117 AS patients (46 had CVD and 71 had no CVD) were enrolled in this retrospective study. The percentage and absolute number of lymphocytes and CD4+T cells were determined by flow cytometry. Associations between CVD and clinical markers were analysed using logistic regression. Results The ratio of Th17/Treg cells (0.30 vs 0.19, P = 0.014) and the absolute number of Th17 cells (7.27 cells/mu L vs 4.34 cells/mu L, P < 0.001) was significantly elevated in AS-CVD group compared with AS-no-CVD group. Multivariate logistic regression revealed that elevated Th17 cells (OR = 1.20, P = 0.016) were associated with CVD complications in AS. Receiver operating characteristic (ROC) curves showed a contribution of Th17 cell for distinguishing AS patients with CVD, with the areas under the ROC curve (AUCs) of 0.729 (95% CI: 0.632, 0.825, P < 0.001). Conclusion Our findings provide evidence for the association between Th17 cells and increased cardiovascular risk in AS. Th17 cells may contribute to accelerated atherogenesis and increased cardiovascular burden in AS and be valuable for early assessment and management of AS-CVD.