The role of IL-1 in the corticotropin-releasing factor and arginine- vasopressin-induced secretion of immunoreactive beta-endorphin by human peripheral blood mononuclear cells.
The role of IL-1 in the corticotropin-releasing factor and arginine- vasopressin-induced secretion of immunoreactive beta-endorphin by human peripheral blood mononuclear cells.
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IL-1 在促肾上腺皮质激素释放因子和精氨酸-加压素诱导的人外周血单核细胞分泌免疫反应性 β-内啡肽中的作用。
作者：
A. Kavelaars;R. E. Ballieux;C. Heijnen
促肾上腺皮质激素释放因子（CRF）和精氨酸加压素（AVP）刺激人PBMC分泌β-内啡肽。这里显示，外周血B细胞在与CRF和AVP培养后负责β-内啡肽的产生。然而，CD 14+单核细胞的存在是CRF和AVP活性增强的先决条件。本文提供的数据表明，rIL-1 β可以替代CRF和AVP，而针对IL-1的mAb消除了对CRF和AVP的反应。这些结果表明，IL-1介导CRF和AVP对人PBMC产生β-内啡肽的影响。
Corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) stimulate the secretion of beta-endorphin by human PBMC. It is shown here that peripheral blood B cells are responsible for the production of beta-endorphin after culture with CRF and AVP. The presence of CD14+ monocytes is, however, a prerequisite for the enhancing activity of CRF and AVP. The data presented here show that rIL-1 beta can replace CRF and AVP, whereas a mAb directed against IL-1 abrogates the response to CRF and AVP. These results indicate that IL-1 mediates the effect of CRF and AVP on beta-endorphin production by human PBMC.