The genetics of Graves' disease
The genetics of Graves' disease
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DOI：
10.1016/s0889-8529(05)70130-4
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发表时间：
2000-06-01
影响因子：
4.5
通讯作者：
Gough, SCL
中科院分区：
文献类型：
--
作者：
Gough, SCL
基于人群的病例对照和基于家族的候选基因研究发现，6p21染色体上的人类白细胞抗原区域和2q33染色体上的细胞毒性t淋巴细胞相关抗原4基因区域在Graves病的发展中起重要作用。全基因组搜索还揭示了与Graves病相关的三个染色体区域，包括染色体14q31 （GD-1）、染色体20q11.2 （GD-2）和Xq21,33-22 （GD-3）的X染色体，其中包含许多新的Graves病候选基因，这些基因尚未在进一步的数据集中进行测试。随着更详细的遗传图谱的出现，以及更多候选基因的定位，确定所有的克瑞夫斯病易感位点成为一个现实的目标。
Population-based case control and family-based candidate gene studies have identified an important role in the development of Graves' disease for the human leukocyte antigen region on chromosome 6p21 and the cytotoxic T-lymphocyte-associated antigen 4 gene region on chromosome 2q33. Genome-wide searches also have revealed three chromosomal regions of linkage to Graves' disease, including chromosome 14q31 (GD-1), chromosome 20q11.2 (GD-2), and the X chromosome at Xq21,33-22 (GD-3), harboring a number of novel candidate genes for Graves' disease that have yet to be tested in further data sets. As more detailed genetic maps emerge, with locations of more candidate genes, the identification of all susceptibility loci for Craves' disease becomes a realistic goal.