Improvement of hydrophilicity and cell attachment of polycaprolactone scaffolds using green synthesized carbon dots
Improvement of hydrophilicity and cell attachment of polycaprolactone scaffolds using green synthesized carbon dots
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DOI：
10.1016/j.mtsust.2021.100075
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发表时间：
2021-07-30
影响因子：
7.8
通讯作者：
Massah, F.
中科院分区：
文献类型：
--
作者：
Ehtesabi, H.;Massah, F.
聚己内酯（PCL）因其生物相容性和生物力学特性而受到广泛的研究。然而，弱亲水性限制了其在支架辅助组织工程中的应用。本文研究了利用碳点（cd）溶液对PCL支架进行表面改性，以提高PCL支架的亲水性。随后进行间充质细胞生长，进一步研究和分析支架的生物学功能。我们的研究结果表明，细胞增殖和附着在修饰的支架上有所改善。基于cd的支架具有表面粗糙度、孔隙结构、亲水性和生物相容性。对程序情况、结构制造和功能优化进行了仔细筛选。因此，这种实用的PCL修饰技术提供了更多具有可调节设计和理想性能的智能生物医学支架和组织工程试剂。(c) 2021 Elsevier Ltd.版权所有。
Scaffolds obtained from polycaprolactone (PCL) have received extensive explorations due to their biocompatibility and biomechanical features. Nevertheless, weak hydrophilicity limits their application for scaffold-aided tissue engineering. In this work, surface modification of PCL scaffolds by using the carbon dots (CDs) solutions was examined to increasing the hydrophilic property of PCL scaffolds. Mesenchymal cell growth followed up to further investigation and analysis on the biologic functions of the scaffolds. Our findings show an improvement in cell proliferation and attachment to the modified scaffold. The CD-based scaffold possessed surface roughness, pore structure, hydrophilicity, and biocompatibility. The procedural situation, structural manufacture, and optimizing the functionality were screened carefully. Thus, this practical technique of PCL modification gives more intelligent biomedical scaffolds and tissue engineering agents with adjustable designs and desirable performances. (c) 2021 Elsevier Ltd. All rights reserved.