Non-osmotic’ hydrogels: a rational strategy for safely degradable hydrogels.
Non-osmotic’ hydrogels: a rational strategy for safely degradable hydrogels.
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非渗透水凝胶：安全可降解水凝胶的合理策略。
DOI：
10.1002/ange.201602610
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Sakai T.
中科院分区：
文献类型：
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作者：
Kamata H;Kushiro K;Takai M;Chung U;Sakai T.
水凝胶是用于生物医学应用的有前途的材料，其中通常优选及时降解。然而，在常规设计中，聚合物网络的断裂基本上引起相当大的形态变化（即，降解引起的肿胀），引发各种医疗并发症。在此，我们报告了一种合理的策略，以抑制降解诱导的溶胀的基础上合成控制的聚合物-溶剂相互作用参数（χ）的组成聚合物网络。具有最佳X参数（X 37 °C <0.53;非弹性水凝胶）的所得水凝胶显示出在生理条件下（X 37 °C<lkPa）保持其原始形状并降解而不产生显著溶胀压力的能力。 这种可安全降解的非渗透性水凝胶的概念在理论上是通用的，并且可以在各种环境中用于其他类型的合成水凝胶。
Hydrogels are promising materials for biomedical applications, where timely degradation is often preferred. In the conventional design, however, the cleavage of polymer networks essentially causes considerable morphological changes (i.e., degradation‐induced swelling), triggering various medical complications. Herein, we report a rational strategy to suppress the degradation‐induced swelling based on the synthetic control of the polymer–solvent interaction parameter (χ) of constituent polymer networks. The resultant hydrogels with an optimalχparameter (χ37 °C≈0.53; non‐osmostic hydrogels) displayed the capability to retain their original shape and degrade without generating significant swelling pressure under physiological conditions (Π37 °C<1 kPa). This concept of the safely degradable non‐osmotic hydrogel is theoretically universal, and can be exploited for other types of synthetic hydrogels in various settings.