Comparative analyses of bidirectional promoters in vertebrates.
Comparative analyses of bidirectional promoters in vertebrates.
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DOI：
10.1186/1471-2105-9-s6-s9
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发表时间：
2008-05-28
影响因子：
3
通讯作者：
Elnitski L
中科院分区：
文献类型：
--
作者：
Yang MQ;Taylor J;Elnitski L
具有较深系统发育历史的直系同源基因可能保留类似的调控特征。在这份报告中，我们利用正交分配的双向启动子共同调控的基因对映射的启动子区域的祖先的历史。我们从人类到鱼类的双向启动子的定位显示，许多这样的启动子出现在鸡和鱼的分歧之后。此外，注释启动子在深同源性使检测缺失的数据或组装问题存在于高等脊椎动物。双向启动子的功能的重要性是由选择压力，以保持在很长的进化时间跨度由启动子调控的基因的排列。双向启动子特有的特征使用称为ESPERR的无监督分类技术进一步阐明。这些分析的结果将有助于我们理解双向启动子的进化，包括两个基因的调控是否是由于它们的接近而进化的，或者功能是否决定了它们的共同调控。
Orthologous genes with deep phylogenetic histories are likely to retain similar regulatory features. In this report we utilize orthology assignments for pairs of genes co-regulated by bidirectional promoters to map the ancestral history of the promoter regions. Our mapping of bidirectional promoters from humans to fish shows that many such promoters emerged after the divergence of chickens and fish. Furthermore, annotations of promoters in deep phylogenies enable detection of missing data or assembly problems present in higher vertebrates. The functional importance of bidirectional promoters is indicated by selective pressure to maintain the arrangement of genes regulated by the promoter over long evolutionary time spans. Characteristics unique to bidirectional promoters are further elucidated using a technique for unsupervised classification, known as ESPERR. Results of these analyses will aid in our understanding of the evolution of bidirectional promoters, including whether the regulation of two genes evolved as a consequence of their proximity or if function dictated their co-regulation.