A new pollen-derived microcarrier for pantoprazole delivery
A new pollen-derived microcarrier for pantoprazole delivery
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DOI：
10.1016/j.msec.2016.11.009
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发表时间：
2017-02-01
影响因子：
7.9
通讯作者：
Akata, Ilgaz
中科院分区：
文献类型：
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作者：
Akyuz, Lalehan;Sargin, Idris;Akata, Ilgaz
植物源性载体是一种很有前途的药物包封材料。特别是从多种花粉中提取的孢粉微胶囊，由于其生物相容性、大小均匀性、耐恶劣化学条件和高热稳定性，已被证明是有效的药物载体。本研究成功地从一种常见树木（欧洲榛子Cotylus avellana）的花粉中分离出孢粉素微胶囊，并将其作为质子泵抑制剂泮托拉唑（PaNa）的载体。药物包封率为29.81%。扫描电镜显示，药物通过微胶囊的孔被加载到微胶囊中，并有部分药物吸附在微胶囊表面。傅里叶变换红外光谱分析证实了载药量。热重分析表明，包封提高了聚丙烯腈的热稳定性。体外释放试验表明，载聚氰胺孢子粉微胶囊的释放性能优于对照。孢粉素微胶囊是一种高效的pa载体。(C) 2016 Elsevier B.V.版权所有
Plant-derived carriers have emerged as promising materials for drug encapsulation. Especially, sporopollenin microcapsules extracted from diverse pollen species have been proved to be effective drug carriers due to their biocompatibility, homogeneity in size, resistance to harsh chemical conditions and high thermal stability. Here in this study, sporopollenin microcapsules were isolated successfully from the pollens of a common tree (Cotylus avellana, the European hazelnut) and used as a carrier for pantoprazole (PaNa) (a proton pump inhibitor). The drug entrapment efficiency was recorded as 29.81%. SEM micrographs clearly showed the drug was loaded into the microcapsules through the apertures of microcapsule and also some drugs were adsorbed on the surface of microcapsules. FT-IR spectra analysis confirmed the drug loading. Thermogravimetric analysis revealed that thermal stability of PaNa was enhanced by encapsulation. In vitro release studies showed that PaNa-loaded sporopollenin microcapsules exhibited better release performance than the control. C. avellana sporopollenin micro capsules can make an efficient carrier for delivery of PaNa. (C) 2016 Elsevier B.V. All rights reserved.