Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes
Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes
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DOI：
10.1099/jgv.0.000751
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发表时间：
2017-05-01
影响因子：
3.8
通讯作者：
Yuen, Kwok-Yung
中科院分区：
文献类型：
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作者：
Lee, Andrew C. Y.;To, Kelvin K. W.;Yuen, Kwok-Yung
大多数感染甲型禽流感H7N9病毒（H7N9）的患者病情严重，伴有细胞因子/趋化因子反应失调、病毒清除延迟和中和抗体反应受损。在这里，我们评估了外周血单核细胞（PBMC）在H7N9感染的发病机制中的作用，使用离体感染模型。H7N9感染PBMC的百分率（23.9%）显著高于H5 N1（12.3%）和H1N1（5.5%）（P
Most patients with avian influenza A H7N9 virus (H7N9) infection suffer from severe illness, accompanied by dysregulated cytokine/chemokine response, delayed viral clearance and impaired neutralizing antibody response. Here, we evaluated the role of peripheral blood mononuclear cells (PBMCs) in the pathogenesis of H7N9 infection using an ex vivo infection model. H7N9 infected a significantly higher percentage of PBMCs (23.9 %) than those of avian influenza A H5N1 virus (H5N1) (12.3 %) and pandemic H1N1 virus (pH1N1) (5.5 %) (P