Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein.
Structure and Function of the Human Respiratory Syncytial Virus M2-1 Protein.
复制标题
人类呼吸道合胞病毒 M2-1 蛋白的结构和功能。
DOI：
10.1007/978-981-10-8456-0_11
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发表时间：
2018
影响因子：
--
通讯作者：
Muniyandi S
中科院分区：
文献类型：
--
作者：
Muniyandi S
Human respiratory syncytial virus (HRSV) is a non-segmented negative stranded RNA virus and is recognized as the most important viral agent of lower respiratory tract infection worldwide, responsible for up to 199,000 deaths each year. The only FDA-approved regime to prevent HRSV-mediated disease is pre-exposure administration of a humanized HRSV-specific monoclonal antibody, which although being effective, is not in widespread usage due to its cost. No HRSV vaccine exists and so there remains a strong need for alternative and complementary anti-HRSV therapies. The HRSV M2–1 protein is a transcription factor and represents an attractive target for the development of antiviral compounds, based on its essential role in the viral replication cycle. To this end, a detailed analysis of M2–1 structure and functions will aid in identifying rational targets for structure-based antiviral drug design that can be developed in future translational research. Here we present an overview of the current understanding of the structure and function of HRSV M2–1, drawing on additional information derived from its structural homologues from other related viruses.
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影响因子：
6.7
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
Becker, Stephan
DOI：
10.1073/pnas.160259697
发表时间：
2000-08-01
影响因子：
11.1
作者：
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通讯作者：
Wolynes, PG