Anti-inflammatory genes associated with multiple sclerosis: A gene expression study
Anti-inflammatory genes associated with multiple sclerosis: A gene expression study
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DOI：
10.1016/j.jneuroim.2015.01.004
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发表时间：
2015-02-15
影响因子：
3.3
通讯作者：
Bertolotto, A.
中科院分区：
文献类型：
--
作者：
Perga, S.;Montarolo, F.;Bertolotto, A.
多发性硬化症（multiple sderosis，MS）是一种多基因与环境因素复杂相互作用引起的中枢神经系统自身免疫性炎症性疾病，HLA区域是最强的易感位点，但近年来大量的全基因组关联研究发现了新的易感基因。其中，BACH 2、PTGER 4、RGS1和ZFP 36L1被重点提及。在这里，基因表达分析显示，与健康受试者相比，其中三个，即BACH2，PTGER4和ZFP36L1，在MS患者的血细胞中下调。有趣的是，所有这些基因都参与免疫系统调节，具有主要的抗炎作用，它们的减少可能易患MS。(C)2015 Elsevier B.V.版权所有。
Multiple sderosis (MS) is an autoimmune inflammatory disease of the central nervous system caused by a complex interaction between multiple genes and environmental factors.HLA region is the strongest susceptibility locus, but recent huge genome-wide association studies identified new susceptibility genes. Among these, BACH2, PTGER4, RGS1 and ZFP36L1 were highlighted. Here, a gene expression analysis revealed that three of them, namely BACH2, PTGER4 and ZFP36L1, are down-regulated in MS patients' blood cells compared to healthy subjects. Interestingly, all these genes are involved in the immune system regulation with predominant anti-inflammatory role and their reduction could predispose to MS development. (C) 2015 Elsevier B.V. All rights reserved.