Organization of rodent auditory cortex: anterograde transport of PHA-L from MGv to temporal neocortex.
Organization of rodent auditory cortex: anterograde transport of PHA-L from MGv to temporal neocortex.
复制标题
啮齿动物听觉皮层的组织：PHA-L 从 MGv 顺行运输到颞叶新皮层。
DOI：
10.1093/cercor/3.6.499
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
LeDoux,JE
中科院分区：
文献类型：
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作者：
Romanski,LM;LeDoux,JE
在本研究中，我们利用顺行轴突示踪剂寻常phaseolus vulgarisleucoglutinin分析了丘脑特异性听觉传递核（内侧膝状体腹侧区）的丘脑皮质投射组织。所有注射MGv均在颞叶皮层产生密集的轴突纤维标记。在所有病例中，标记的轴突主要集中在皮层III层和IV层，并且在较小程度上集中在V层和VI层的交界处。将注射限制在MGv的医学区域，特别是MGv的避免核（OV，旁侧），导致TE1的顺行标记，TE1的腹侧四分之一有少量标记，称为TE1v亚区。注射于上颌窦侧区并占据外侧腹侧亚核（LV），或注射于上颌窦中外侧中心并占据部分LV和OV，也会导致TE1区域标记和TE1v轻微标记。然而，这些注射也在TE2和TE3区域产生标记。因此，TE1区域（不包括TE1v子区域）受到来自MGv各方面的大量投影，似乎是MGv的核心目标。虽然中枢性脑脊液区域也投射到周围的皮质带区域，但这些投射往往更轻，并且根据所检查的中枢性脑脊液区域而变化。这些结果，连同其他连接发现，以及细胞结构学和生理学研究，表明TE1（可能不包括TE1v亚区）是大鼠的初级听觉皮层。
In the present study we analyzed the organization of the thalamocortical projections of the specific auditory relay nucleus of the thalamus, the ventral division of the medial geniculate body (MGv), using the anterograde axonal tracerPhaseolus vulgarisleucoagglutinin. All injections of MGv produced dense labeling of axonal fibers in temporal cortex. In all cases, labeled axons were predominantly concentrated in cortical layers III and IV and, to a lesser extent, at the junction of layers V and VI. Injections confined to the medical regions of MGv, and specifically to the avoid nucleus of MGv (OV, parsovoidea), resulted in anterograde labeling of TE1, with minor labeling of the ventral quarter of TE1, designated subarea TE1v. Injections placed in lateral regions of MGv and occupying the lateral ventral subnucleus (LV), or injections in the mediolateral center of MGv and occupying parts of LV and OV, also resulted in labeling of area TE1 and minor labeling of TE1v. However, these injections also produced labeling in areas TE2 and TE3. Thus, area TE1 (excluding subarea TE1v) receives heavy projections from all aspects of MGv and appears to be the core target of MGv. While regions of MGv also project to surrounding cortical belt areas, these projections tend to be lighter and to vary depending on the region of MGv examined. These results, together with other connectional findings, and cytoarchitectonic and physiological studies, suggest that TE1 (possibly excluding subarea TE1v) is the primary auditory cortex in the rat.