Simple and reproducible hepatectomy in the mouse using the clip technique
Simple and reproducible hepatectomy in the mouse using the clip technique
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DOI：
10.3748/wjg.v18.i22.2767
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发表时间：
2012-06-14
影响因子：
4.3
通讯作者：
Nguyen, Justin H.
中科院分区：
文献类型：
--
作者：
Hori, Tomohide;Ohashi, Norifumi;Nguyen, Justin H.
目的：方法：对100只小鼠在肝脏缩小> 70%的情况下进行大面积肝切除术后的解剖学表现进行分析。不同模型中各种因素的影响也进行了分析，包括学习曲线，手术时间，生存曲线，和组织病理学findings.Results：根据解剖结果，模型与75%，80%，和90%肝切除产生巨大的hepatectonny。学习曲线和手术时间是最佳的夹技术。每一个肝切除术使用夹技术产生了合理的生存曲线，并有缝合和夹technology.CONCLUSION之间的组织病理学结果没有差异：大块肝切除术的夹技术是简单，可以提供可靠的相关数据。(C)2012年百世登。All rights reserved.
AIM: To investigate the reliability of massive hepatectomy models by using clip techniques.METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectonny. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques.CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. (C) 2012 Baishideng. All rights reserved.