The role of the PMd in task complexity: functional connectivity is modulated by motor learning and age
The role of the PMd in task complexity: functional connectivity is modulated by motor learning and age
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DOI：
10.1016/j.neurobiolaging.2020.03.016
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发表时间：
2020-08-01
影响因子：
4.2
通讯作者：
Pauwels, Lisa
中科院分区：
文献类型：
--
作者：
Maes, Celine;Swinnen, Stephan P.;Pauwels, Lisa
背侧运动前皮层（PMd）在运动任务的控制和学习中起着关键作用，特别是在任务复杂度较高的情况下。本研究旨在探讨任务复杂性的影响下，在老化的背景下，使用心理生理相互作用分析的PMD种子的功能连接。年轻和老年参与者参加了为期3天的培训方案，其中获取了与任务相关的功能性磁共振成像数据。在训练过程中，运动是内部产生的或外部产生的在线视觉反馈的存在或不存在，分别。行为结果表明，老年人往往有更多的困难与复杂的任务变量相比，年轻的成年人。在神经层面上，老年人表现出灵活调整他们的神经资源依赖于所提供的反馈的困难。此外，PMD种子连接相关的行为任务的复杂性指数在两个年龄组，虽然介导的年龄。总之，这些结果突出了PMD在适应任务复杂性及其年龄相关影响的重要性。
The dorsal premotor cortex (PMd) plays a key role in the control and learning of motor tasks, especially when task complexity is high. This study sought to investigate the effect of task complexity on PMd-seeded functional connectivity in the context of aging using psychophysiological interaction analyses. Young and older participants were enrolled in a 3-day training protocol whereby task-related functional magnetic resonance imaging data were acquired. During training, movement was either internally generated or externally generated in the absence or presence of online visual feedback, respectively. Behavioral results indicated that older adults tended to have more difficulties with the complex task variants as compared with young adults. On a neural level, older adults demonstrated difficulties in flexibly adjusting their neural resources dependent on the feedback provided. Furthermore, PMd-seeded connectivity was related to a behavioral task complexity index in both age groups, albeit mediated by age. Together, these results highlight the importance of PMd in adaptability to task complexity and its age-related effects.