Trans-omic profiling between clinical phenoms and lipidomes among patients with different subtypes of lung cancer
Trans-omic profiling between clinical phenoms and lipidomes among patients with different subtypes of lung cancer
复制标题
不同亚型肺癌患者临床现象和脂质组之间的跨组学分析
DOI：
10.1002/ctm2.151
复制
发表时间：
2020-08-01
影响因子：
10.6
通讯作者：
Wang, Xiangdong
中科院分区：
文献类型：
--
作者：
Zhu, Zhenhua;Zhang, Linlin;Wang, Xiangdong
肺癌死亡率高，常伴有全身代谢紊乱。本研究旨在确定腺癌（ADC）、鳞状细胞癌或小细胞肺癌（SCLC）患者的跨结节跨临床表型和脂质组学网络层的值。我们测量了肺癌患者的血浆脂质组学特征，发现改变的脂质组和浓度在肺癌亚型、性别、年龄、分期、转移状态、营养状态和临床表型严重程度之间存在差异。结果表明，磷脂酰乙醇胺元素（36：2，18：0/18：2和18：1/18：1）是SCLC特异性的，而溶血磷脂酰胆碱（20：1和22：0 sn-位置-1）和磷脂酰胆碱（19：0/19：0和19：0/21：2）是ADC特异性的。男性血脂水平下降明显，
Lung cancer has high mortality, often accompanied with systemic metabolic disorders. The present study aimed at defining values of trans-nodules cross-clinical phenomic and lipidomic network layers in patients with adenocarcinoma (ADC), squamous cell carcinomas, or small cell lung cancer (SCLC). We measured plasma lipidomic profiles of lung cancer patients and found that altered lipid panels and concentrations varied among lung cancer subtypes, genders, ages, stages, metastatic status, nutritional status, and clinical phenome severity. It was shown that phosphatidylethanolamine elements (36:2, 18:0/18:2, and 18:1/18:1) were SCLC specific, whereas lysophosphatidylcholine (20:1 and 22:0 sn-position-1) and phosphatidylcholine (19:0/19:0 and 19:0/21:2) were ADC specific. There were statistically more lipids declined in male,