ALTERATIONS IN SERUM PROPERDIN LEVELS FOLLOWING INJECTION OF ZYMOSAN
ALTERATIONS IN SERUM PROPERDIN LEVELS FOLLOWING INJECTION OF ZYMOSAN
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DOI：
10.1126/science.121.3151.732
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发表时间：
1955-01-01
期刊：
影响因子：
56.9
通讯作者：
ROSS, OA
中科院分区：
文献类型：
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作者：
PILLEMER, L;ROSS, OA
7132进入小鼠体内后，小鼠对实验性大肠杆菌感染的敏感性发生了显著变化。在注射酵母多糖后的第一个小时内，小鼠对一种对正常小鼠无毒力的大肠杆菌菌株变得高度敏感。此外，在注射酵母多糖后的2至5天内，小鼠对另一种对正常小鼠完全毒力的大肠杆菌菌株具有高度抵抗力。此外，罗利发现，如果在挑战前1小时注射酵母多糖，对大肠杆菌感染具有天然抵抗力的老鼠就会被这种细菌杀死。这些实验表明，在Rowley实验中，我们所发现的酵母多糖给药后血液中的备解素的初始下降和继发升高可能影响动物的自然抵抗力的增减。将在其他地方详细发表的实验(5)还表明，将酵母多糖注射到小鼠或大鼠体内可以显著增加或降低它们对致命剂量全身照射的敏感性，具体取决于注射的剂量和时间。
7132 into mice caused marked changes in their susceptibility to experimental Escherichia coli infection. During the first hour after zymosan injection, the mice became highly susceptible to infection with an E. coli strain that was avirulent for normal mice. Moreover, during the period between 2 and 5 days after injection of zymosan, the mice were highly resistant to a different E. coli strain that was fully virulent for normal mice. In addition, Rowley found that rats which are naturally resistant to E. coli infection were killed by this organism if zymosan had been injected with 1 hr preceding challenge. These experiments suggest that the initial fall and secondary rise in blood properdin that we have found to follow zymosan administration may influence the increase and decrease in natural resistance of the ani-mals in Rowley's experiments. Experiments to be published in detail elsewhere (5) also show that the injection of zymosan into mice or rats can markedly increase or decrease their susceptibility to the effects of lethal doses of total-body irradiation depending on the dose and the time of injection.