Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion.
Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion.
复制标题
人血小板糖蛋白 V：一种与粘附相关的表面富含亮氨酸的糖蛋白。
DOI：
10.1016/0006-291x(90)91253-o
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发表时间：
1990
影响因子：
3.1
通讯作者：
Williams,SA
中科院分区：
文献类型：
--
作者：
Roth,GJ;Church,TA;McMullen,BA;Williams,SA
人血小板糖蛋白V（Mr 82，000）是一种表面糖蛋白，也是凝血酶的底物，通过凝血酶进行蛋白水解切割并释放可溶性片段，即糖蛋白Vfl（Mr 69，000）。它似乎不是凝血酶对血小板的激动剂作用的受体。一种先天性血小板疾病，Bernard-Soulier综合征，以糖蛋白V和另外两种表面糖蛋白Ib-IX缺乏为特征。后两个，Ib-IX，构成血管性血友病因子的血小板受体，介导动脉血小板粘附，并含有独特的24个氨基酸序列，称为“富含亮氨酸的糖蛋白”片段。这些片段与粘附功能有关，并区分了富含亮氨酸的糖蛋白家族。表面糖蛋白V与Ib-IX没有物理联系，也不与血管性血友病因子结合。到目前为止，还没有发现共同的分母来解释在Bernard-Soulier综合征中糖蛋白V和Ib-IX的联合缺乏。本研究描述了糖蛋白V/抗糖蛋白V抗体的分离和三个糖蛋白V肽，含有“亮氨酸丰富”序列的分析。因此，糖蛋白V与血小板糖蛋白Ib-IX共享“富亮氨酸”结构，并且属于富亮氨酸糖蛋白家族。
Human platelet glycoprotein V (Mr 82,000) is a surface glycoprotein and a substrate for thrombin, undergoing proteolytic cleavage by thrombin and releasing a soluble fragment, glycoproteinVfl(Mr 69,000). It does not appear to be the receptor for thrombin's agonist effect on platelets. A congenital platelet disorder, Bernard-Soulier syndrome, is marked by a deficiency of glycoprotein V and two other surface glycoproteins, Ib-IX. The latter two, Ib-IX, constitute the platelet receptor for von Willebrand factor, mediate arterial platelet adhesion, and contain unique 24-amino acid sequences, termed “leucine-rich glycoprotein” segments. The segments relate to adhesive function and distinquish the leucine-rich glycoprotein family. Surface glycoprotein V is not physically associated with Ib-IX nor does it bind to von Willebrand factor. To date, no common denominator has been found that explains the combined deficiency of glycoproteins V and Ib-IX in Bernard-Soulier syndrome. This study describes the isolation of glycoprotein V/anti-glycoprotein V antibody and the analysis of three glycoprotein V peptides that contain “leucine-rich” sequences. Therefore, glycoprotein V shares the “leucine-rich” structure with platelet glycoproteins Ib-IX and belongs to the family of leucine-rich glycoproteins.