Rosemary extract improves cognitive deficits in a rats model of repetitive mild traumatic brain injury associated with reduction of astrocytosis and neuronal degeneration in hippocampus
Rosemary extract improves cognitive deficits in a rats model of repetitive mild traumatic brain injury associated with reduction of astrocytosis and neuronal degeneration in hippocampus
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迷迭香提取物可改善重复性轻度创伤性脑损伤大鼠模型的认知缺陷，并减少海马星形细胞增多和神经元变性
DOI：
10.1016/j.neulet.2016.04.048
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发表时间：
2016-05-27
影响因子：
2.5
通讯作者：
Yu, Jianyun
中科院分区：
文献类型：
--
作者：
Song, Hai;Xu, Lincheng;Yu, Jianyun
本研究探讨迷迭香提取物（RE）是否能改善重复性轻度创伤性脑损伤（rmTBI）大鼠的认知缺陷及其可能机制。本研究结果表明，rmTBI引起认知缺陷，如Morris水迷宫（MWM）中寻找平台的潜伏期增加，目标象限的停留时间减少。这些行为改变伴随着海马神经元变性和胶质纤维酸性蛋白（GFAP）阳性细胞增加，活性氧（ROS）生成增加，超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和过氧化氢酶（CAT）活性降低，IL-1 β、IL-6和tnf - α蛋白水平升高。用RE治疗可防止上述变化。本研究结果证实了迷迭香提取物对认知缺陷的改善作用，并提示其机制可能与抗氧化和抗炎有关。因此，迷迭香提取物可能是改善rmTBI患者认知缺陷的潜在治疗方法。2016爱思唯尔爱尔兰有限公司版权所有。
In this study, we investigated whether Rosemary extract (RE) improved cognitive deficits in repetitive mild Traumatic brain injury (rmTBI) rats and its potential mechanisms. The present results showed that rmTBI caused cognitive deficits, such as increased latency to find platform and decreased time spent in target quadrant in Morris water maze (MWM). These behavioral alterations were accompanying with the increased neuronal degeneration and glial fibrillary acidic protein (GFAP)-positive cells, increased Reactive oxygen species (ROS) generation, decreased activity of Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT), elevated protein level of IL-1 beta, IL-6 and TNF-alpha in hippocampus. Treatment with RE prevented these changes above. Our findings confirmed the effect of rosemary extract on improvement of cognitive deficits and suggested its mechanisms might be mediated by anti-oxidative and anti-inflammatory. Therefore, rosemary extract may be a potential treatment to improve cognitive deficits in rmTBI patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.