Glucose repression on RIM1, a gene encoding a mitochondrial single-stranded DNA-binding protein, in Saccharomyces cerevisiae:: a possible regulation at pre-mRNA splicing
Glucose repression on RIM1, a gene encoding a mitochondrial single-stranded DNA-binding protein, in Saccharomyces cerevisiae:: a possible regulation at pre-mRNA splicing
复制标题
DOI：
10.1007/s002940050406
复制
发表时间：
1998-12-01
期刊：
影响因子：
2.5
通讯作者：
Shibata, T
中科院分区：
文献类型：
--
作者：
Li, ZJ;Ling, F;Shibata, T
线粒体单链DNA结合蛋白（SSB）由核基因RIM 1编码，是大肠杆菌SSB的同源物。葡萄糖的加入降低了在甘油培养基中生长的细胞中的RIM 1-mRNA的量，但增加了未成熟的RIM 1-mRNA的量。成熟和未成熟的RIM 1-mRNA的量的变化依赖于SRN 1/REG 1/HEX 2，一个与前mRNA剪接和葡萄糖抑制相关的基因。这些观察结果表明，线粒体SSB的表达，至少部分地，由前体mRNA剪接葡萄糖阻遏的控制下进行调节。
The mitochondrial single-stranded DNA-binding protein (SSB) encoded by a nuclear gene, RIM1, is a homolog of Escherichia coli SSB. The addition of glucose decreased the amount of RIM1-mRNA in cells growing in a glycerol medium, but increased the amount of the immature RIM1-mRNA. The changes in the amounts of both mature and immature RIM1-mRNAs were dependent on SRN1/REG1/HEX2, a gene relating to pre-mRNA-splicing and glucose repression. These observations suggest that the expression of the mitochondrial SSB is regulated, at least in part, by pre-mRNA splicing under the control of glucose repression.