Ethnic disparities in pain processing among healthy adults: μ-opioid receptor binding potential as a putative mechanism.
Ethnic disparities in pain processing among healthy adults: μ-opioid receptor binding potential as a putative mechanism.
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健康成年人疼痛处理的种族差异：μ-阿片受体结合潜力作为一种推定机制。
DOI：
10.1097/j.pain.0000000000001759
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发表时间：
2020
期刊：
影响因子：
7.4
通讯作者：
Campbell,ClaudiaM
中科院分区：
文献类型：
--
作者：
Letzen,JanelleE;Mun,ChungJung;Kuwabara,Hiroto;Burton,EmilyF;Boring,BrandonL;Walls,Taylor;Speed,TraciJ;Wong,DeanF;Campbell,ClaudiaM
虽然疼痛感知的种族差异有很好的记录，但这些结果的潜在机制尚未建立。M-阿片受体（莫尔）功能可能导致这种差异，因为MOR在疼痛敏感性和调节中起关键作用。然而，没有研究表明莫尔生理学的种族差异。本研究试图通过检查27名非西班牙裔黑人（NHB）和27名人口统计学相似的非西班牙裔白色受试者之间的m-选择性激动剂结合潜力（BPND;[11 C]-卡芬太尼）差异来解决这一知识差距。参与者完成了问卷调查和两个90分钟的高分辨率研究断层扫描正电子发射断层扫描（PET）成像会议。在PET成像过程中，将辣椒素或对照霜涂抹在受试者的手臂上，并收集疼痛评分。Bonferroni校正的PET感兴趣体积分析显示，NHB参与者双侧腹侧纹状体的[11 C]-卡芬太尼BPND显著更高（[左]：F1，52 5 16.38，P，0.001;[右]：F1，52 5 21.76，P，0.001），双侧背外侧前额叶皮层（[左] F1，52 5 17.3，P，0.001;[右]：F1，52 5 14.17，P，0.001），双侧膝下前扣带皮质（[左]：F1，52 5 10.4，P 5 0.002;[右]：F1，52 5 12.91，P 5 0.001）和右股骨颈（F1，52 5 11.0，P 5 0.002）。然而，在各模型中，条件或种族3条件相互作用效应没有显著的主效应，这可能归因于组内变化方向的个体变异性。BPND值与辣椒素条件下收集的疼痛评分显著相关（r范围5 0.34-0.46，P范围5 0.01-0.001）。结果表明，NHB个人可能有更大的空闲莫尔密度比非西班牙裔白色同行。研究结果对种族相关疼痛差异的生理差异有影响。如果复制，这些结果进一步强调了在历史上服务不足的人群中进行量身定制治疗的必要性。
Although ethnic differences in pain perception are well documented, the underlying mechanism for these outcomes has not been established. m-opioid receptor (MOR) function might contribute to this disparity, given that MORs play a key role in pain sensitivity and modulation. However, no study has characterized ethnic differences in MOR physiology. This study sought to address this knowledge gap by examining differences in m-selective agonist binding potential (BPND;[11C]-Carfentanil) between 27 non-Hispanic black (NHB) and 27 demographically similar, non-Hispanic white participants. Participants completed questionnaires and two 90-minute high-resolution research tomograph positron emission tomography (PET) imaging sessions. During PET imaging, a capsaicin or control cream was applied to individuals’ arms, and pain ratings were collected. Bonferroni-corrected PET volumes of interest analyses revealed significantly greater [11C]-Carfentanil BPND among NHB participants in bilateral ventral striatum ([left]: F1, 52 5 16.38, P, 0.001;[right]: F1, 52 5 21.76, P, 0.001), bilateral dorsolateral prefrontal cortex ([left] F1, 52 5 17.3, P, 0.001;[right]: F1, 52 5 14.17, P, 0.001), bilateral subgenual anterior cingulate cortex ([left]: F1, 52 5 10.4, P 5 0.002;[right]: F1, 52 5 12.91, P 5 0.001), and right insula (F1, 52 5 11.0, P 5 0.002). However, there were no significant main effects of condition or ethnicity 3 condition interaction effects across models, likely attributable to individual variability in the direction of change within groups. BPND values were significantly correlated with pain ratings collected during the capsaicin condition (r range 5 0.34-0.46, P range 5 0.01-0.001). Results suggest that NHB individuals might have generally greater unoccupied MOR density than non-Hispanic white peers. Findings have implications for physiological differences underlying ethnicity-related pain disparities. If replicated, these results further emphasize the need for tailored treatments in historically underserved populations.